| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase PLSTIRE |
| Entrez GeneID | 1021; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around aa.11~15 (Q-Q-Y-E-C) derived from Human CDK6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CDK6(Ab-13)抗体的参考文献示例(部分内容为模拟，实际文献需根据具体检索结果确认)：
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1. **"CDK6 expression correlates with poor prognosis in breast cancer"**
*Author: Smith A, et al. (2018)*
摘要：研究通过免疫组化(使用CDK6 Ab-13抗体)分析乳腺癌组织中CDK6蛋白水平，发现其高表达与肿瘤侵袭性和患者生存率下降相关，提示CDK6作为潜在治疗靶点。
2. **"Targeting CDK6 in T-cell acute lymphoblastic leukemia"**
*Author: Lee J, et al. (2020)*
摘要：利用CDK6 Ab-13抗体进行Western blot和流式细胞术，证明抑制CDK6可阻滞白血病细胞周期进程，为CDK6抑制剂开发提供实验依据。
3. **"CDK6 regulates hematopoietic stem cell quiescence"**
*Author: Wang Y, et al. (2019)*
摘要：通过CDK6 Ab-13抗体检测小鼠造血干细胞中的蛋白表达，揭示CDK6在维持干细胞静息状态中的关键作用，缺失导致异常增殖。
4. **"Validation of CDK6 antibody specificity in solid tumors"**
*Author: Garcia R, et al. (2021)*
摘要：系统评估CDK6 Ab-13抗体的特异性，对比多种肿瘤样本，确认其在免疫荧光和免疫沉淀中的可靠性，支持其在临床前研究中的应用。
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**说明**：
- 上述文献为示例，实际需通过PubMed、Google Scholar或抗体供应商(如Thermo Fisher)官网的“引用文献”部分检索确认。
- CDK6(Ab-13)常见于细胞周期、癌症机制或靶向治疗研究，实验方法多涉及Western blot、IHC或流式细胞术。
- 若未明确提及Ab-13克隆号，可参考抗体说明书或联系厂商获取被引研究。
CDK6 (Cyclin-Dependent Kinase 6) is a serine/threonine kinase that plays a critical role in regulating cell cycle progression, primarily by forming complexes with D-type cyclins (e.g., cyclin D1. D2. D3) to drive the G1-to-S phase transition. It phosphorylates and inactivates retinoblastoma (Rb) protein, releasing E2F transcription factors to promote DNA replication and cell division. CDK6 is also implicated in transcriptional regulation, stem cell maintenance, and differentiation, with dysregulation linked to cancers, such as leukemia, lymphoma, and solid tumors. Its overexpression or hyperactivity is often associated with uncontrolled proliferation and therapeutic resistance.
The CDK6 (Ab-13) antibody is a monoclonal antibody specifically designed to detect endogenous CDK6 protein levels in various experimental applications, including Western blotting (WB), immunohistochemistry (IHC), and immunoprecipitation (IP). It targets a conserved epitope within the kinase domain, ensuring high specificity and minimal cross-reactivity with homologous kinases like CDK4. Validated in multiple cell lines and tissue samples, this antibody aids in studying CDK6 expression patterns, functional interactions, and its role in disease mechanisms. Researchers utilize it to explore CDK6 inhibition strategies, assess biomarker potential in oncology, or investigate cell cycle deregulation in preclinical models. Its reliability makes it a key tool in both basic research and drug development targeting CDK6-related pathways.
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