| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C-erbB-2; ErbB2; |
| Entrez GeneID | 2064; |
| WB Predicted band size | 185kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa. 1246~1250 (P-E-Y-L-G) derived from Human HER2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HER2(Ab-1248)抗体的虚构参考文献示例(仅供格式参考，实际文献需通过学术数据库查询)：
1. **"HER2(Ab-1248) Antibody Validation in Breast Cancer Prognosis"**
*Authors: Smith J, et al.*
**摘要**：本研究验证了HER2(Ab-1248)抗体在乳腺癌组织中的特异性，证明其可用于免疫组化(IHC)检测HER2过表达，与患者预后显著相关。
2. **"Targeted Therapy Screening Using HER2(Ab-1248)-Based Assays"**
*Authors: Lee H, et al.*
**摘要**：开发了一种基于HER2(Ab-1248)抗体的高通量筛选方法，用于评估HER2阳性肿瘤对曲妥珠单抗的耐药性，揭示了新的联合治疗靶点。
3. **"Comparative Study of HER2 Antibodies in Circulating Tumor Cell Detection"**
*Authors: Garcia R, et al.*
**摘要**：对比HER2(Ab-1248)与其他商用抗体的性能，发现其在循环肿瘤细胞(CTC)检测中灵敏度更高，支持其作为液体活检工具的应用。
**注意**：以上文献为模拟内容，实际研究中请通过 **PubMed/Google Scholar** 搜索关键词：`HER2 Ab-1248 antibody validation/therapy/detection`，并筛选近年高被引论文。
HER2 (Ab-1248) is a monoclonal antibody specifically targeting the human epidermal growth factor receptor 2 (HER2), a transmembrane tyrosine kinase receptor encoded by the *ERBB2* gene. HER2 plays a critical role in regulating cell proliferation, differentiation, and survival by forming homodimers or heterodimers with other EGFR family members (e.g., HER1. HER3. HER4). Overexpression or amplification of HER2 is observed in approximately 15-20% of breast cancers and subsets of gastric, ovarian, and other solid tumors, correlating with aggressive disease and poor prognosis.
The Ab-1248 clone is commonly used in research and diagnostic applications, particularly in immunohistochemistry (IHC), to detect HER2 protein expression levels in formalin-fixed, paraffin-embedded (FFPE) tissue samples. Its specificity for the intracellular domain of HER2 enables reliable identification of HER2-positive tumors, aiding in patient stratification for HER2-targeted therapies like trastuzumab (Herceptin®) or pertuzumab.
Unlike therapeutic antibodies, HER2 (Ab-1248) is primarily a diagnostic tool, validated for clinical use in some regions to guide treatment decisions. Its performance is benchmarked against standardized scoring systems (e.g., ASCO/CAP guidelines) to ensure consistency in HER2 status assessment. Ongoing research continues to explore its utility in understanding HER2 signaling dynamics, resistance mechanisms, and novel therapeutic combinations.
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