| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NR3C3; PGR; PRGR |
| Entrez GeneID | 5241; |
| WB Predicted band size | 99kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa.188~192 (G-L-S-P-A) derived from Human Progesterone Receptor. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 Progesterone Receptor (Ab-190) 抗体的模拟参考文献示例(注：以下内容为假设性示例，实际文献需通过学术数据库查询)：
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1. **文献名称**: *"Differential Expression of Progesterone Receptor Isoforms in Breast Cancer"*
**作者**: Smith A, et al.
**摘要**: 本研究使用 Progesterone Receptor (Ab-190) 抗体通过免疫组化分析乳腺癌组织中 PR-A 和 PR-B 亚型的表达差异，发现 PR-B 高表达与更好的预后相关。
2. **文献名称**: *"Validation of Progesterone Receptor Antibody Specificity in Reproductive Tissues"*
**作者**: Johnson R, Lee C.
**摘要**: 文章验证了 Ab-190 抗体在子宫内膜和卵巢组织中的特异性，通过 Western blot 和免疫荧光证实其与 PR 蛋白的强结合能力，无交叉反应性。
3. **文献名称**: *"Hormonal Regulation of PR in Endometrial Cancer Models"*
**作者**: Brown K, et al.
**摘要**: 研究利用 Ab-190 抗体探究雌激素和孕酮对子宫内膜癌细胞中 PR 表达的动态调控，发现激素撤退导致 PR 表达下调并促进细胞凋亡。
4. **文献名称**: *"Progesterone Receptor Signaling in Ovarian Follicle Development"*
**作者**: Garcia M, et al.
**摘要**: 通过 Ab-190 抗体检测小鼠卵巢组织中 PR 的时空表达模式，揭示其在卵泡成熟和黄体化过程中的关键作用。
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**建议**：如需真实文献，可访问 PubMed 或 Google Scholar，搜索关键词 **"Progesterone Receptor Ab-190 antibody"**，并筛选目标物种(如人、小鼠)或应用场景(如 IHC、WB)。部分抗体厂商官网(如 CST、Santa Cruz)也会提供引用其产品的文献列表。
The Progesterone Receptor (PR) Ab-190 antibody is a monoclonal antibody commonly used to detect the progesterone receptor, a nuclear hormone receptor critical for mediating progesterone's effects in reproductive tissues, mammary glands, and other target organs. PR exists as two major isoforms, PR-A and PR-B, generated from a single gene via alternative promoter usage. The Ab-190 clone specifically recognizes an epitope within the N-terminal region of human PR, enabling differentiation between PR isoforms in research applications.
Progesterone receptors play pivotal roles in regulating gene transcription upon ligand activation, influencing processes such as endometrial differentiation, embryo implantation, mammary gland development, and cellular proliferation. Clinically, PR expression is a key biomarker in breast cancer diagnostics, as hormone receptor status (ER/PR) guides therapeutic decisions, including endocrine therapy. The Ab-190 antibody is widely utilized in immunohistochemistry (IHC), Western blotting, and immunofluorescence (IF) to assess PR expression levels and subcellular localization in both research and clinical pathology settings. Its specificity and reliability make it a valuable tool for studying progesterone signaling pathways, hormone-dependent cancers, and reproductive biology. Validation typically includes testing on PR-positive cell lines or tissues, with cross-reactivity confirmed in human and select model organisms.
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