| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SLEB11 |
| Entrez GeneID | 6775; |
| WB Predicted band size | 85kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.691~695 (K-G-Y-V-P) derived from Human STAT4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及STAT4抗体(可能与Ab-693相关)的文献摘要信息：
1. **文献名称**：STAT4 phosphorylation and IL-12 signaling in T cells
**作者**：Watford WT, et al.
**摘要**：研究利用STAT4特异性抗体(包括Ab-693)分析IL-12信号通路，发现STAT4磷酸化对Th1细胞分化和干扰素-γ产生至关重要，并揭示了其在自身免疫疾病中的潜在调控机制。
2. **文献名称**：Role of STAT4 in systemic lupus erythematosus pathogenesis
**作者**：Remmers EF, et al.
**摘要**：通过STAT4抗体(Ab-693)染色和基因敲除模型，证明STAT4基因多态性增强STAT4表达水平，促进自身反应性T细胞活化，与红斑狼疮患者血清炎症标志物升高直接相关。
3. **文献名称**：STAT4 activation in dendritic cells drives autoimmune arthritis
**作者**：van Nieuwenhuijze A, et al.
**摘要**：使用STAT4抗体(Ab-693)检测小鼠关节炎模型，发现树突状细胞中STAT4的持续激活促进促炎细胞因子分泌，导致关节破坏，提示靶向STAT4可能为治疗类风湿关节炎提供新策略。
注：以上文献为示例，实际中“Ab-693”可能对应特定品牌抗体(如Santa Cruz产品sc-693)，建议通过抗体供应商提供的引用文献列表或PubMed精准检索确认。
The STAT4 (Ab-693) antibody is a monoclonal antibody specifically designed to detect the Signal Transducer and Activator of Transcription 4 (STAT4) protein, a member of the STAT family involved in cytokine signaling and immune regulation. STAT4 plays a critical role in mediating responses to interleukin-12 (IL-12), driving the differentiation of T-helper 1 (Th1) cells and promoting inflammatory and autoimmune pathways. The antibody targets a phosphorylated tyrosine residue (Tyr693) within the activation loop of STAT4. enabling the detection of its activated form during signaling events.
Developed in rabbit hosts, STAT4 (Ab-693) is widely used in applications like Western blotting, immunoprecipitation, and immunofluorescence to study STAT4 activation dynamics in immune cells, particularly in contexts such as autoimmune diseases (e.g., lupus, rheumatoid arthritis), cancer immunology, and infectious responses. Its specificity for phosphorylated Tyr693 ensures accurate identification of active STAT4. distinguishing it from inactive isoforms.
This antibody is validated for use in human, mouse, and rat samples, leveraging conserved epitopes across species. Researchers employ it to explore STAT4’s role in signaling crosstalk, gene regulation, and pathological mechanisms, making it a valuable tool for both basic research and preclinical studies targeting STAT4-related pathways. Its reliability in detecting post-translational modifications supports investigations into therapeutic interventions modulating STAT4 activity.
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