| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Retrotransposon gag domain-containing protein 4, RGAG4, KIAA2001 |
| Entrez GeneID | 340526 |
| WB Predicted band size | 64.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RGAG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 418-446 amino acids from the C-terminal region of human RGAG4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RGAG4抗体的虚构参考文献示例(仅供参考，实际文献需通过学术数据库验证)：
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1. **文献名称**：*RGAG4 Expression and Localization in Human Testicular Germ Cells*
**作者**：Smith A, et al.
**摘要**：本研究利用特异性RGAG4抗体，通过免疫组化技术揭示了RGAG4蛋白在人类睾丸生殖细胞中的定位，提示其可能在精子发生过程中发挥调控作用。
2. **文献名称**：*RGAG4 as a Potential Biomarker in Ovarian Cancer*
**作者**：Johnson R, et al.
**摘要**：通过Western blot和免疫荧光技术，研究者发现RGAG4抗体在卵巢癌组织中高表达，可能与肿瘤细胞增殖和转移相关。
3. **文献名称**：*Autoantibodies Against RGAG4 in Autoimmune Disorders*
**作者**：Lee H, et al.
**摘要**：该研究检测到系统性红斑狼疮患者血清中RGAG4抗体水平升高，提示其可能参与自身免疫反应的病理机制。
4. **文献名称**：*RGAG4 Interaction with RNA-Binding Proteins in Cellular Stress Response*
**作者**：Garcia M, et al.
**摘要**：利用RGAG4抗体进行免疫共沉淀实验，发现RGAG4与多种RNA结合蛋白相互作用，可能在细胞应激条件下调控RNA稳定性。
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**注意**：以上内容为模拟生成，实际文献需通过PubMed、Web of Science等平台检索确认。若需具体文献，建议提供更详细的研究背景或验证关键词准确性。
The RGAG4 antibody targets the RGAG4 protein, a member of the G antigen (GAG) family encoded by retrogene-derived sequences on the X chromosome. RGAG4 is a primate-specific protein believed to originate from the domestication of a retrotransposon Gag gene, a process where viral elements are repurposed for cellular functions. Structurally, it retains conserved features of ancestral retroviral Gag proteins, including motifs involved in nucleic acid binding and oligomerization.
RGAG4 is predominantly expressed in germ cells and certain cancer types, suggesting roles in gametogenesis and tumorigenesis. Studies link it to X chromosome inactivation (XCI) and genomic stability, potentially influencing epigenetic regulation. Its aberrant expression in cancers, particularly germ cell tumors, has drawn interest as a possible diagnostic or prognostic biomarker.
The RGAG4 antibody is widely used in research to investigate its localization, interaction partners, and mechanistic contributions to cellular processes. Applications include Western blotting, immunohistochemistry, and immunofluorescence to study RGAG4's expression patterns in normal and pathological tissues. Its development has advanced understanding of retroelement-derived proteins in human biology, highlighting their dual roles as drivers of evolution and disease. Ongoing research explores RGAG4's therapeutic potential as a target for cancer or fertility-related interventions.
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