Rabbit Polyclonal ABCB11 Antibody

The ABCB11 antibody targets the bile salt export pump (BSEP), a protein encoded by the *ABCB11* gene, primarily expressed in hepatocyte canalicular membranes. BSEP plays a critical role in transporting bile acids from liver cells into bile, a process essential for digestion and lipid absorption. Dysregulation of BSEP function is linked to cholestatic liver disorders, such as progressive familial intrahepatic cholestasis type 2 (PFIC2) and drug-induced liver injury. ABCB11 antibodies are vital tools in research and diagnostics, enabling detection of BSEP expression levels, localization, or mutations via techniques like immunohistochemistry, Western blotting, or immunofluorescence. These antibodies help elucidate molecular mechanisms underlying bile acid homeostasis and disease pathogenesis. Clinically, they aid in diagnosing genetic cholestasis syndromes or assessing acquired BSEP deficiencies. Additionally, ABCB11 antibodies are used in drug development to evaluate potential hepatotoxicity caused by BSEP inhibition. Structural studies utilizing these antibodies have mapped key domains, such as ATP-binding sites and transmembrane regions, advancing understanding of BSEP’s transport mechanics. Despite challenges like post-translational modifications affecting antigen recognition, ABCB11 antibodies remain indispensable for studying liver physiology and developing targeted therapies for cholestatic diseases.