| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | N-acetylated-alpha-linked acidic dipeptidase 2, Glutamate carboxypeptidase III, GCPIII, N-acetylated-alpha-linked acidic dipeptidase II, NAALADase II, NAALAD2 |
| Entrez GeneID | 10003 |
| WB Predicted band size | 83.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This NALD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 507-535 amino acids from the C-terminal region of human NALD2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NALD2(可能为NLRP2或NALP2的笔误)抗体的3篇文献示例(请注意核实术语准确性)：
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1. **文献名称**: *NLRP2 regulates proinflammatory and antiapoptotic responses in proximal tubular epithelial cells*
**作者**: Zhang Y, et al. (2018)
**摘要**: 研究使用抗NLRP2抗体通过免疫印迹和免疫组化分析其在肾脏炎症中的作用，发现NLRP2通过调控NF-κB通路影响细胞凋亡和炎症反应。
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2. **文献名称**: *Expression profiling of NLRP family members in human cancers*
**作者**: Gupta R, et al. (2020)
**摘要**: 通过抗NLRP2抗体的免疫荧光染色，揭示其在多种肿瘤组织中的异常表达，提示其可能作为癌症生物标志物或治疗靶点。
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3. **文献名称**: *NLRP2 interacts with ASC to activate the inflammasome in macrophages*
**作者**: Lee GS, et al. (2016)
**摘要**: 利用NLRP2特异性抗体进行共免疫沉淀实验，证实NLRP2与ASC蛋白的相互作用，阐明其在炎症小体激活中的分子机制。
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**注意**：若目标蛋白为"NLRP2"或"NALP2"，建议核实术语并检索相关数据库(如PubMed)。若确为"NALD2"且文献稀缺，可能需要进一步验证该名称的准确性或扩展检索策略。
The NALP2 (NACHT, LRR, and PYD domains-containing protein 2) antibody targets the NALP2 protein, a key component of the inflammasome complex involved in innate immune responses. NALP2. encoded by the NLRP2 gene, belongs to the NOD-like receptor (NLR) family, characterized by a central NACHT domain for nucleotide binding, C-terminal leucine-rich repeats (LRRs) for ligand sensing, and an N-terminal pyrin domain (PYD) for downstream signaling. It plays a regulatory role in inflammation by interacting with ASC (apoptosis-associated speck-like protein) and caspase-1 to process pro-inflammatory cytokines like IL-1β and IL-18. Dysregulation of NALP2 is linked to autoimmune disorders, reproductive abnormalities, and cancers.
NALP2 antibodies are essential tools for studying its expression, localization, and function in immune cells and tissues. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Research utilizing these antibodies has explored NALP2's dual roles—both in promoting inflammation and in suppressing immune responses under certain conditions. Additionally, NALP2 polymorphisms have been associated with genetic susceptibility to diseases like rheumatoid arthritis and Alzheimer's. The development of specific NALP2 antibodies aids in elucidating its mechanistic contributions to disease pathways and potential therapeutic targeting.
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