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Rabbit Polyclonal METTL4 Antibody

  • 中文名: METTL4抗体
  • 别    名: Methyltransferase-like protein 4, 211-, METTL4
货号: IPDX34785
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/25 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMethyltransferase-like protein 4, 211-, METTL4
Entrez GeneID64863
WB Predicted band size54.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis METTL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-344 amino acids from the C-terminal region of human METTL4.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于METTL4抗体的3篇参考文献示例(注:部分文献信息为示例性概括,建议通过学术数据库核实具体内容):

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1. **文献名称**:*"METTL4-mediated N4-acetylcytidine modification is required for mitochondrial function"*

**作者**:Wei, J., et al. (2022)

**摘要**:该研究揭示了METTL4通过催化RNA的N4-乙酰胞苷(ac4C)修饰调控线粒体基因表达。研究中使用特异性METTL4抗体进行免疫沉淀和蛋白质印迹,验证了METTL4在线粒体中的定位及其与RNA结合的能力。

2. **文献名称**:*"METTL4 catalyzes adenine DNA methylation to regulate transcription and cell cycle"*

**作者**:Xiong, X., et al. (2020)

**摘要**:本文发现METTL4是一种新型DNA腺嘌呤甲基转移酶,参与细胞周期调控。研究者通过开发兔源多克隆METTL4抗体,结合ChIP-seq技术,证实METTL4在基因组特定区域的甲基化修饰及其对转录的抑制作用。

3. **文献名称**:*"Structural and functional analysis of the METTL4 methyltransferase in RNA modification"*

**作者**:Li, Y., et al. (2021)

**摘要**:该研究解析了METTL4的晶体结构,并阐明其催化RNA修饰的分子机制。实验中利用抗METTL4抗体进行免疫荧光和蛋白质互作分析,揭示了METTL4在细胞核内的功能网络及其与癌症发生的潜在关联。

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**备注**:上述文献标题及内容为基于METTL4相关研究的合理示例,具体文献可能需要通过PubMed、Web of Science等平台以“METTL4 antibody”或“METTL4 methyltransferase”等关键词检索获取最新信息。

背景信息

The METTL4 antibody is a research tool designed to detect and study the METTL4 protein, a member of the methyltransferase-like (METTL) family involved in epigenetic regulation. METTL4 is implicated in transferring methyl groups to biological molecules, potentially influencing RNA or DNA modification processes. While its exact substrates and mechanisms remain under investigation, METTL4 is suggested to play roles in transcriptional regulation, cellular differentiation, and genome stability. Antibodies targeting METTL4 enable researchers to investigate its expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Recent studies link METTL4 to diseases such as cancer, where aberrant methylation patterns contribute to tumor progression or therapy resistance. These antibodies are critical for exploring METTL4's functional relevance in epigenetic pathways and its potential as a biomarker or therapeutic target. Commercial METTL4 antibodies are typically validated for specificity and sensitivity across human, mouse, or rat models, supporting diverse experimental applications in molecular biology and oncology research. Ongoing work aims to clarify METTL4's precise biological functions and its interplay with other methyltransferases in health and disease.

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