Rabbit Polyclonal TECPR1 Antibody

The TECPR1 (tectonin beta-propeller repeat-containing protein 1) antibody is a tool used to study the TECPR1 protein, a conserved eukaryotic protein implicated in autophagy and intracellular trafficking. TECPR1 contains β-propeller domains, structural motifs often involved in protein-protein interactions. Research highlights its role in autophagosome-lysosome fusion, where it interacts with ATG8/LC3 family proteins to mediate membrane tethering, a critical step in autophagic degradation. Dysregulation of TECPR1 is linked to neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), and infections, as it may recognize pathogen-associated molecular patterns. Antibodies against TECPR1 enable detection of its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These studies contribute to understanding autophagy mechanisms, cellular stress responses, and disease pathology. Commercially available TECPR1 antibodies are typically validated in human, mouse, or rat models, aiding research in neurobiology, cancer, and infectious diseases. However, specificity validation (e.g., knockout controls) is essential due to potential cross-reactivity with structurally similar proteins. Ongoing research explores TECPR1's therapeutic potential, emphasizing its role in maintaining proteostasis and combating protein aggregation-related diseases.