Rabbit Polyclonal HSPA1A/HSPA1B(Y41) Antibody

The HSPA1A and HSPA1B genes encode two nearly identical isoforms of the 70 kDa heat shock protein (HSP70), critical molecular chaperones involved in cellular stress response, protein folding, and apoptosis regulation. These proteins are induced under stress conditions such as heat shock, oxidative stress, or nutrient deprivation. The "Y41" epitope refers to phosphorylation at tyrosine residue 41. a post-translational modification implicated in modulating HSP70’s functional interactions, including its ATPase activity and binding to co-chaperones or client proteins. Antibodies targeting HSPA1A/HSPA1B phosphorylated at Y41 (e.g., anti-HSPA1A/B Y41) are valuable tools for studying stress-induced signaling pathways and protein quality control mechanisms. They enable researchers to detect and quantify this specific modification under physiological or pathological conditions, such as cancer, neurodegenerative diseases, or ischemia-reperfusion injury, where HSP70 dysregulation is observed. These antibodies are commonly validated for applications like Western blotting, immunofluorescence, and immunoprecipitation. However, users must confirm cross-reactivity between HSPA1A and HSPA1B due to their high sequence homology, and verify specificity against other HSP70 family members. Understanding Y41 phosphorylation dynamics provides insights into stress adaptation mechanisms and potential therapeutic targets for diseases linked to proteostasis imbalance.