| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Thioredoxin-interacting protein, Vitamin D3 up-regulated protein 1, Txnip, Vdup1 |
| Entrez GeneID | 56338 |
| WB Predicted band size | 44.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Txnip antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the Central region of mouse Txnip. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于小鼠TXNIP抗体的3篇文献参考(基于公开数据概括，非真实文献)：
1. **文献名称**: *"TXNIP regulates NLRP3 inflammasome activation in diabetic β-cell dysfunction"*
**作者**: Chen J et al.
**摘要**: 本研究利用TXNIP特异性抗体(针对小鼠模型)，通过免疫印迹和免疫组化证实，高糖环境下胰岛β细胞中TXNIP表达上调，并激活NLRP3炎症小体，导致细胞凋亡。抗体验证了TXNIP在糖尿病病理中的关键作用。
2. **文献名称**: *"TXNIP deficiency protects against oxidative stress-induced retinal degeneration via AMPK signaling"*
**作者**: Yoshihara E et al.
**摘要**: 作者使用TXNIP敲除小鼠及特异性抗体，发现TXNIP缺失通过增强AMPK通路减轻氧化应激对视网膜细胞的损伤。抗体用于检测视网膜组织中TXNIP蛋白水平变化。
3. **文献名称**: *"TXNIP mediates hepatic steatosis in non-alcoholic fatty liver disease through lipid metabolism modulation"*
**作者**: Kim SY et al.
**摘要**: 该研究通过Western blot和免疫荧光(使用小鼠TXNIP抗体)证明，TXNIP在肝脏脂质蓄积中起调控作用，抑制TXNIP可改善脂肪变性，提示其作为治疗靶点的潜力。
4. **文献名称**: *"TXNIP links mitochondrial dysfunction to myocardial ischemia-reperfusion injury"*
**作者**: Zhou Y et al.
**摘要**: 利用小鼠心脏缺血再灌注模型，通过TXNIP抗体检测发现，TXNIP表达升高与线粒体功能受损相关，敲低TXNIP可减轻心肌细胞损伤。
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注：以上为模拟示例，实际文献需通过PubMed/Google Scholar检索关键词“Mouse TXNIP antibody”或“TXNIP immunohistochemistry”等获取。
**Background of Mouse Txnip Antibody**
The mouse Txnip (Thioredoxin-interacting protein) antibody is a tool used to detect and study Txnip, a protein encoded by the *Txnip* gene in mice. Txnip, also known as VDUP1 (Vitamin D3 Upregulated Protein 1) or TBP-2 (Thioredoxin-Binding Protein-2), plays a critical role in cellular redox regulation by binding to thioredoxin (Trx), inhibiting its antioxidant activity, and promoting oxidative stress. It is involved in diverse physiological processes, including glucose metabolism, apoptosis, inflammation, and tumor suppression.
Txnip expression is regulated by metabolic and stress signals, such as high glucose levels, hypoxia, and oxidative stress. In research, mouse Txnip antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate Txnip's role in diseases such as diabetes, cancer, and neurodegenerative disorders. These antibodies specifically target epitopes unique to mouse Txnip, enabling species-specific studies in murine models.
The development and validation of high-affinity mouse Txnip antibodies have been pivotal in uncovering its dual role as both a stress-response regulator and a metabolic modulator, providing insights into therapeutic strategies targeting oxidative stress-related pathologies.
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