| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Adiponectin receptor protein 2, Progestin and adipoQ receptor family member II, ADIPOR2, PAQR2 |
| Entrez GeneID | 79602 |
| WB Predicted band size | 43.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ADIPOR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-72 amino acids from the Central region of human ADIPOR2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ADIPOR2抗体的3篇参考文献示例(文献信息为模拟示例，仅供参考)：
1. **"ADIPOR2 expression in human adipose tissue and its role in adipocyte differentiation"**
- **作者**: Smith A, et al.
- **摘要**: 该研究通过Western blot和免疫组化分析ADIPOR2在人类脂肪组织中的表达，发现ADIPOR2抗体检测显示其在肥胖患者中表达下调，并证实其通过AMPK通路调控脂肪细胞分化。
2. **"ADIPOR2 modulates hepatic insulin sensitivity via ceramide metabolism"**
- **作者**: Tanaka Y, et al.
- **摘要**: 利用ADIPOR2抗体在小鼠肝脏组织中进行免疫沉淀实验，发现ADIPOR2通过调节神经酰胺代谢改善胰岛素抵抗，为代谢综合征治疗提供潜在靶点。
3. **"ADIPOR2 antibody-based detection in prostate cancer progression"**
- **作者**: Lee C, et al.
- **摘要**: 研究采用ADIPOR2抗体进行免疫组化染色，发现前列腺癌组织中ADIPOR2表达水平与肿瘤侵袭性呈负相关，提示其可能作为癌症预后的生物标志物。
4. **"ADIPOR2 interacts with APPL1 to mediate adiponectin signaling in skeletal muscle"**
- **作者**: Wu X, et al.
- **摘要**: 通过免疫共沉淀(使用ADIPOR2抗体)和荧光显微镜技术，揭示了ADIPOR2与接头蛋白APPL1的相互作用机制，及其在骨骼肌细胞中调控葡萄糖摄取的作用。
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**注意**：以上文献为示例，实际引用时需核实真实数据库(如PubMed、Web of Science)中的最新研究。
The ADIPOR2 (Adiponectin Receptor 2) antibody is a key tool for studying the role of ADIPOR2. a membrane-bound receptor involved in metabolic regulation. ADIPOR2. encoded by the ADIPOR2 gene, binds adiponectin—an adipocyte-secreted hormone critical for glucose and lipid metabolism. Unlike typical G protein-coupled receptors, ADIPOR2 features a unique seven-transmembrane structure with an internal N-terminus and external C-terminus. It activates downstream pathways like AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-alpha (PPARα), enhancing fatty acid oxidation, glucose uptake, and insulin sensitivity.
ADIPOR2 antibodies, often developed in hosts like rabbits or mice, are widely used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to detect protein expression, localization, and interactions. These antibodies help elucidate ADIPOR2's tissue distribution, notably in liver, muscle, and adipose tissue, and its dysregulation in metabolic disorders like obesity, type 2 diabetes, and non-alcoholic fatty liver disease. Research also links ADIPOR2 to inflammatory responses, cancer progression, and cardiovascular diseases, highlighting its therapeutic potential. Validation of antibody specificity via knockout controls or siRNA knockdown is essential to ensure accurate detection, given structural similarities with ADIPOR1. Such studies advance understanding of adiponectin signaling and its implications in metabolic health.
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