| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5, NLRP6, NALP6, PYPAF5 |
| Entrez GeneID | 171389 |
| WB Predicted band size | 98.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NLRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the N-terminal region of human NLRP6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于NLRP6 (N-term)抗体的参考文献概览：
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1. **"NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis"**
*Elinav, E. et al. (2011), Nature.*
摘要：首次报道NLRP6在肠道炎症中的调控作用，通过生成NLRP6 (N-term)特异性抗体验证其在肠上皮细胞的表达，并揭示其通过调控微生物群抑制肠道炎症的机制。
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2. **"Dysbiosis and the Immune System"**
*Levy, M. et al. (2015), Cell.*
摘要：研究NLRP6介导的宿主-菌群互作，使用NLRP6 N端抗体进行免疫印迹(Western Blot)和免疫组化，证明其在前列腺素合成及炎症反应中的关键作用。
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3. **"The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection"**
*Hara, H. et al. (2018), Cell Host & Microbe.*
摘要：利用NLRP6 (N-term)抗体在小鼠模型中验证蛋白表达，阐明NLRP6识别革兰氏阳性菌细胞壁成分并调控先天免疫反应的分子机制。
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4. **"NLRP6 Modulates Neutrophil Homeostasis in Bacterial Pneumonia"**
*Wlodarska, M. et al. (2014), Immunity.*
摘要：通过NLRP6 N端抗体进行免疫共沉淀和免疫荧光实验，揭示其在肺中性粒细胞募集和细菌性肺炎中的保护性功能。
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这些文献均应用NLRP6 N端抗体进行蛋白定位、表达验证或功能研究，涵盖肠道、肺部及全身性免疫调控。建议通过PubMed或期刊官网获取全文核对实验细节。
The NLRP6 (N-terminal) antibody targets the N-terminal region of the NLRP6 protein, a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family. NLRP6 is a key component of the inflammasome, a multiprotein complex that regulates innate immune responses by activating caspase-1. leading to the maturation of pro-inflammatory cytokines like IL-18 and IL-1β. It plays a critical role in maintaining mucosal homeostasis, particularly in the gut, by modulating interactions between the host and the microbiota. NLRP6 is also implicated in metabolic disorders, viral immunity, and inflammatory diseases. The N-terminal pyrin domain (PYD) of NLRP6 facilitates protein-protein interactions, enabling inflammasome assembly and downstream signaling.
Antibodies specific to the N-terminal region of NLRP6 are essential tools for studying its expression, localization, and functional mechanisms. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation to investigate NLRP6's role in health and disease. Research utilizing these antibodies has revealed NLRP6's dual role in inflammation—both promoting and suppressing immune responses depending on the context—and its influence on microbial diversity in the gut. Dysregulation of NLRP6 is linked to conditions like colitis, obesity, and liver fibrosis. By enabling precise detection of NLRP6. these antibodies contribute to advancing understanding of inflammasome biology, host-microbe interactions, and potential therapeutic targets for inflammatory and metabolic disorders.
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