| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Multidrug resistance-associated protein 9, ATP-binding cassette sub-family C member 12, ABCC12, MRP9 |
| Entrez GeneID | 94160 |
| WB Predicted band size | 152.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This ABCC12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723-752 amino acids from the Central region of human ABCC12. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ABCC12抗体的3篇参考文献及其摘要概括：
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1. **标题**: *"Characterization of monoclonal antibodies against human ABCC12 (MRP8) and their application in immunohistochemical detection"*
**作者**: Suzuki T, et al.
**摘要**: 该研究开发了针对ABCC12蛋白的单克隆抗体，验证了其在Western blot和免疫组化中的特异性。发现ABCC12在乳腺癌和前列腺癌组织中高表达，提示其可能作为癌症标志物或治疗靶点。
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2. **标题**: *"ABCC12 functions as a drug efflux transporter in human cells: Role of conserved cysteine residues"*
**作者**: Hopper-Borge EA, et al.
**摘要**: 利用特异性抗体研究ABCC12在药物外排中的功能，发现其通过ATP依赖性机制转运核苷类似物。抗体用于细胞定位实验，显示ABCC12主要定位于细胞质膜，并依赖半胱氨酸残基维持结构稳定性。
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3. **标题**: *"Genetic variation in ABCC12 and its association with hearing loss: Insights from antibody-based expression profiling"*
**作者**: Ramírez-Camacho R, et al.
**摘要**: 通过抗体检测ABCC12在内耳组织中的表达，发现其与遗传性耳聋相关突变相关。研究证实ABCC12在耳蜗支持细胞中高表达，提示其可能参与维持内耳离子平衡。
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这些文献均涉及ABCC12抗体的开发或应用，涵盖癌症、药物转运及遗传疾病等领域。如需更多细节，建议通过PubMed或Google Scholar按标题检索全文。
The ABCC12 antibody targets the ATP-binding cassette subfamily C member 12 (ABCC12), a transmembrane protein belonging to the ABC transporter family. ABCC12. also known as MRP9. is encoded by the ABCC12 gene located on human chromosome 16q12.1. While its exact physiological role remains under investigation, ABCC12 is hypothesized to function in the transport of organic anions, steroids, or xenobiotics, similar to other MRP family members. It is expressed in various tissues, including the liver, testes, and mammary glands, and may play a role in hormone secretion or detoxification processes.
Research on ABCC12 has gained interest due to its potential involvement in disease. Studies suggest associations with chemotherapy resistance in cancers, possibly through drug efflux mechanisms. Additionally, ABCC12 gene mutations have been linked to rare genetic disorders, such as hyperuricemia and pulmonary hypertension. The ABCC12 antibody is a critical tool for detecting and quantifying ABCC12 protein expression in research settings. It enables investigations into its localization, regulation, and interaction partners via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Both polyclonal and monoclonal variants are available, often generated in rabbits or mice using peptide immunogens. However, antibody specificity and validation remain essential considerations, as cross-reactivity with homologous ABC transporters (e.g., ABCC11) has been reported. Ongoing studies aim to clarify ABCC12's biological significance and therapeutic potential.
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