| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Antigen peptide transporter 2, APT2, ATP-binding cassette sub-family B member 3, Peptide supply factor 2, Peptide transporter PSF2, PSF-2, Peptide transporter TAP2, Peptide transporter involved in antigen processing 2, Really interesting new gene 11 protein, TAP2, ABCB3, PSF2, RING11, Y1 |
| Entrez GeneID | 6891 |
| WB Predicted band size | 75.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TAP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 100-134 amino acids from the human region of human TAP2. |
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以下是关于TAP2(N-Term)抗体的3篇参考文献示例(内容基于学术文献常见主题虚构，实际文献需通过数据库检索确认)：
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1. **文献名称**: *"Characterization of TAP2 N-terminal epitope-specific antibodies in antigen processing studies"*
**作者**: Müller et al.
**摘要**: 本研究开发了一种针对TAP2蛋白N端区域的单克隆抗体，用于免疫印迹和免疫荧光实验。实验证明该抗体可特异性识别TAP2在细胞中的表达，并揭示其在MHC I类抗原呈递通路中的亚细胞定位。
2. **文献名称**: *"TAP2 expression analysis in autoimmune disorders using a novel N-terminal antibody"*
**作者**: Chen & Smith
**摘要**: 通过使用针对TAP2 N端的多克隆抗体，研究者发现TAP2在类风湿性关节炎患者的B细胞中表达显著下调，提示其可能与抗原呈递缺陷导致的自身免疫反应相关。
3. **文献名称**: *"Functional disruption of TAP2 by RNA interference validated via N-terminal antibody detection"*
**作者**: Gupta et al.
**摘要**: 该研究利用TAP2(N-Term)抗体验证siRNA敲低TAP2的效果，证实抗体在Western blot中能有效检测TAP2蛋白水平变化，并关联其功能缺失与病毒感染后免疫逃逸现象。
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**提示**：实际文献需通过PubMed或Google Scholar以关键词“TAP2 antibody N-terminal”检索，并筛选涉及抗体开发、验证或功能研究的文章。
The TAP2 (N-Term) antibody is designed to target the N-terminal region of the Transporter Associated with Antigen Processing 2 (TAP2), a critical component of the antigen presentation pathway. TAP2. along with TAP1. forms a heterodimeric complex (TAP1/TAP2) that belongs to the ATP-binding cassette (ABC) transporter family. Located in the endoplasmic reticulum (ER) membrane, this complex facilitates the ATP-dependent transport of cytosolic antigenic peptides into the ER lumen, where they bind to major histocompatibility complex (MHC) class I molecules. This process is essential for immune surveillance, enabling cytotoxic T-cells to recognize and eliminate infected or malignant cells.
Antibodies targeting the N-terminal region of TAP2 are valuable tools for studying its expression, localization, and functional interactions. They are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate TAP2 regulation under physiological or pathological conditions, such as viral immune evasion, autoimmune disorders, or cancer. Dysregulation of TAP2 has been linked to impaired antigen presentation, contributing to immune escape mechanisms in tumors or susceptibility to infections. Research using TAP2 (N-Term) antibodies has also shed light on diseases like bare lymphocyte syndrome (BLS), where TAP deficiencies lead to reduced MHC class I surface expression. These antibodies are often validated for specificity across species, particularly in human and mouse models, ensuring reliability in both basic research and translational studies exploring immune-related pathways.
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