| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein DLX-1, DLX1 |
| Entrez GeneID | 1745 |
| WB Predicted band size | 27.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This DLX1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 84-118 amino acids from the Central region of human DLX1. |
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以下是关于DLX1抗体的3篇示例参考文献(内容为模拟示例，仅供参考)：
1. **《DLX1作为前列腺癌尿液生物标志物的验证研究》**
*作者：Smith A, et al.*
摘要：研究通过ELISA和免疫组化技术，使用DLX1特异性抗体检测前列腺癌患者尿液及组织样本，证实DLX1蛋白高表达与肿瘤侵袭性相关，提示其作为无创诊断标志物的潜力。
2. **《胶质母细胞瘤中DLX1的表达与预后相关性分析》**
*作者：Zhang L, et al.*
摘要：利用DLX1抗体进行Western blot和免疫荧光实验，发现DLX1在胶质瘤干细胞中显著高表达，且与患者生存期缩短相关，提示其在肿瘤恶性进展中的调控作用。
3. **《DLX1在皮层中间神经元发育中的时空表达模式》**
*作者：Tanaka K, et al.*
摘要：通过胚胎小鼠脑组织免疫染色(DLX1抗体)，揭示DLX1在中间神经元迁移过程中的动态表达，证实其对神经元分化及皮层网络形成的必要性。
4. **《诱导多能干细胞神经分化中DLX1的动态调控》**
*作者：Chen R, et al.*
摘要：研究采用DLX1抗体跟踪蛋白表达，发现DLX1在分化为GABA能神经元阶段特异性上调，CRISPR干扰实验进一步验证其对神经亚型特化的关键作用。
(注：以上文献为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索确认。)
The DLX1 antibody is a crucial tool in studying the DLX1 protein, a member of the Distal-less (DLX) family of homeobox transcription factors. DLX genes, conserved across vertebrates, play pivotal roles in embryonic development, particularly in the nervous system, craniofacial patterning, and limb formation. DLX1. specifically, is involved in regulating GABAergic interneuron differentiation, cortical development, and osteogenesis. Dysregulation of DLX1 has been linked to neurodevelopmental disorders, skeletal abnormalities, and cancers such as ovarian and prostate cancer.
The DLX1 antibody enables researchers to detect and quantify DLX1 protein expression in tissues or cells via techniques like immunohistochemistry (IHC), Western blot, or immunofluorescence (IF). It is often used to explore DLX1's spatial-temporal expression patterns during development, its role in disease mechanisms, or its potential as a biomarker. Polyclonal and monoclonal variants exist, typically raised in rabbits or mice against specific DLX1 epitopes. Validation includes testing on knockout controls or tissues with known DLX1 expression.
Recent studies highlight DLX1's association with cancer progression, making its antibody valuable in oncology research. However, cross-reactivity with other DLX family members (e.g., DLX2) requires careful validation to ensure specificity. Overall, the DLX1 antibody is indispensable for unraveling the protein's biological functions and therapeutic implications.
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