| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Juxtaposed with another zinc finger protein 1, TAK1-interacting protein 27, Zinc finger protein 802, JAZF1, TIP27, ZNF802 |
| Entrez GeneID | 221895 |
| WB Predicted band size | 27.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This JAZF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-49 amino acids from the N-terminal region of human JAZF1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于JAZF1 (N-term)抗体的参考文献示例(注：文献为示例性概括，非真实存在，仅供格式参考)：
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1. **文献名称**: *JAZF1 Regulates Glucose Homeostasis via Transcriptional Repression*
**作者**: Smith A et al.
**摘要**: 研究利用JAZF1 (N-term)抗体通过Western blot和免疫荧光技术，揭示JAZF1在胰岛β细胞中通过抑制特定基因表达调控胰岛素分泌的分子机制。
2. **文献名称**: *JAZF1 Overexpression in Endometrial Stromal Tumors*
**作者**: Lee B et al.
**摘要**: 通过免疫组化(使用JAZF1 N端抗体)分析子宫内膜间质肉瘤组织，发现JAZF1蛋白异常高表达与肿瘤侵袭性相关，提示其作为潜在生物标志物。
3. **文献名称**: *JAZF1 Interaction with PPARγ in Adipocyte Differentiation*
**作者**: Garcia C et al.
**摘要**: 研究利用JAZF1 (N-term)抗体进行免疫共沉淀实验，证实JAZF1与PPARγ直接结合，调控脂肪细胞分化和代谢相关基因表达。
4. **文献名称**: *JAZF1 Localization and Epigenetic Regulation in Prostate Cancer*
**作者**: Patel D et al.
**摘要**: 采用JAZF1 N端抗体的免疫荧光技术，发现JAZF1在细胞核内的动态定位，并揭示其通过招募组蛋白修饰酶影响前列腺癌细胞的表观遗传调控。
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如需真实文献，建议在PubMed或Google Scholar中搜索关键词：**JAZF1 antibody N-terminal** 或 **JAZF1 (N-term) antibody application**，并筛选涉及Western blot、IHC、IP等实验技术的文章。部分抗体厂商(如Santa Cruz Biotechnology、Abcam)的产品说明中也可能提供引用文献。
The JAZF1 (N-term) antibody is designed to target the N-terminal region of the JAZF1 protein, a zinc finger transcriptional repressor encoded by the *JAZF1* gene. JAZF1 contains multiple C2H2-type zinc finger domains, which are critical for its role in regulating gene expression by binding to specific DNA sequences or interacting with nuclear receptors. The N-terminal region of JAZF1 is implicated in mediating protein-protein interactions, particularly with nuclear receptors such as TR4 (testicular receptor 4), influencing pathways related to hormone signaling, cellular differentiation, and metabolism.
Research has linked JAZF1 to various physiological and pathological processes. It is notably involved in endometrial stromal cell function and has been associated with endometrial stromal sarcoma due to recurrent chromosomal translocations (e.g., *JAZF1-SUZ12* fusion). Additionally, JAZF1 polymorphisms are linked to metabolic disorders, including type 2 diabetes and polycystic ovary syndrome, highlighting its role in glucose homeostasis and insulin sensitivity.
The JAZF1 (N-term) antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study endogenous JAZF1 expression, localization, and interactions. Its specificity for the N-terminal region ensures detection of full-length JAZF1 while avoiding cross-reactivity with truncated isoforms or fusion proteins. This antibody serves as a crucial tool for elucidating JAZF1's molecular mechanisms in both normal physiology and disease contexts.
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