| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Large neutral amino acids transporter small subunit 2, L-type amino acid transporter 2, hLAT2, Solute carrier family 7 member 8, SLC7A8, LAT2 |
| Entrez GeneID | 23428 |
| WB Predicted band size | 58.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SLC7A8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 476-506 amino acids from human SLC7A8. |
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以下是关于SLC7A8(LAT2)抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: "The amino acid transporter SLC7A8 mediates uptake of L-tryptophan in the kidney"
**作者**: Fukasawa Y, et al.
**摘要**: 本研究利用SLC7A8特异性抗体，通过免疫组化和免疫印迹技术，揭示了SLC7A8在肾脏近端小管细胞基底膜的表达，并证实其与4F2hc(CD98)形成异源二聚体，参与L-色氨酸等中性氨基酸的跨膜转运。
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2. **文献名称**: "Functional characterization of human L-type amino acid transporter 2 (LAT2) in intestinal epithelial cells"
**作者**: Segawa H, et al.
**摘要**: 该研究通过SLC7A8抗体进行蛋白定位分析，发现SLC7A8在小肠上皮细胞的顶膜表达，并证明其与mTOR信号通路相关，在肠道氨基酸吸收及细胞增殖中起关键作用。
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3. **文献名称**: "The SLC7 family of amino acid transporters: roles in cancer and therapeutic targets"
**作者**: Bröer S, et al.
**摘要**: 这篇综述总结了SLC7A8等氨基酸转运蛋白的生理病理功能，并讨论了针对其抗体的实验应用(如Western blot和免疫荧光)，强调了其在肿瘤代谢研究中的潜在价值。
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这些文献均通过SLC7A8抗体验证了该蛋白的表达模式及功能，适用于相关分子机制或疾病研究。
The SLC7A8 antibody targets the solute carrier family 7 member 8 (SLC7A8), a protein encoded by the *SLC7A8* gene in humans. SLC7A8. also known as LAT2 (L-type amino acid transporter 2), is a sodium-independent neutral amino acid transporter belonging to the heteromeric amino acid transporter (HAT) family. It forms a functional heterodimer with SLC3A2 (CD98hc) via a disulfide bond, enabling its cell surface expression and activity. SLC7A8 facilitates the transport of essential amino acids, such as leucine, phenylalanine, and glutamine, across plasma membranes, playing a critical role in cellular nutrient uptake, metabolic regulation, and tissue homeostasis.
This transporter is predominantly expressed in tissues with high metabolic demands, including the kidneys, intestines, placenta, and brain. Its function is linked to renal reabsorption, intestinal absorption of amino acids, and neurotransmitter precursor supply. Dysregulation of SLC7A8 has been implicated in pathologies such as cancer, neurological disorders, and chronic kidney disease, where altered amino acid metabolism contributes to disease progression.
SLC7A8 antibodies are widely used in research to study protein localization, expression levels, and functional roles in physiological and pathological contexts. They are essential tools in techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into amino acid transport mechanisms and their implications in health and disease. Validating antibody specificity is crucial, given the structural similarities among SLC family members.
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