Rabbit Polyclonal SYNE2(N-Term) Antibody

The SYNE2 (N-Term) antibody is a specialized tool used to detect the N-terminal region of the SYNE2 protein, also known as Nesprin-2. SYNE2 belongs to the nesprin family of proteins, which are critical for anchoring the nucleus to the cytoskeleton via interactions with the nuclear envelope and cytoplasmic components. The SYNE2 protein plays a key role in maintaining nuclear structure, cell polarity, and mechanical stability, particularly in mechanically active tissues like muscle and skin. Its N-terminal region contains conserved domains that mediate interactions with actin and other cytoskeletal elements. Dysregulation or mutations in SYNE2 have been linked to various pathologies, including Emery-Dreifuss muscular dystrophy, cardiomyopathy, and cancer metastasis. The SYNE2 (N-Term) antibody is widely used in research applications such as Western blotting, immunofluorescence, and immunohistochemistry to study SYNE2 expression, localization, and function in cellular and tissue contexts. It is especially valuable for investigating mechanisms of nuclear-cytoskeletal coupling, cell migration, and disease-associated alterations. Researchers often validate this antibody using knockout controls or siRNA-mediated SYNE2 knockdown to ensure specificity. Its utility spans developmental biology, cancer research, and studies of neuromuscular disorders, making it a crucial reagent for understanding SYNE2's role in health and disease.