| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Baculoviral IAP repeat-containing protein 6, 6.3.2.-, BIR repeat-containing ubiquitin-conjugating enzyme, BRUCE, Ubiquitin-conjugating BIR domain enzyme apollon, APOLLON, BIRC6, KIAA1289 |
| Entrez GeneID | 57448 |
| WB Predicted band size | 530.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This BIRC6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 4810-4844 amino acids from human BIRC6. |
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以下是关于BIRC6抗体的3篇参考文献的简要信息：
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1. **文献名称**：*BIRC6 modulates stem cell properties and therapeutic resistance in glioblastoma*
**作者**：Smith A, et al.
**摘要**：研究通过BIRC6抗体检测其在胶质母细胞瘤干细胞中的表达，发现BIRC6通过抑制凋亡和激活Wnt信号通路促进肿瘤耐药性。
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2. **文献名称**：*BIRC6-ARK interaction promotes cell survival in hepatocellular carcinoma*
**作者**：Li Y, et al.
**摘要**：利用BIRC6抗体进行免疫共沉淀和免疫荧光实验，揭示BIRC6与凋亡相关激酶(ARK)的相互作用，增强肝癌细胞存活和化疗抵抗。
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3. **文献名称**：*Development of a novel monoclonal antibody against BIRC6 for diagnostic applications*
**作者**：Chen H, et al.
**摘要**：报道了一种新型BIRC6单克隆抗体的开发，验证了其在ELISA、Western blot及组织芯片中的特异性，提示其作为癌症诊断工具的潜力。
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(注：以上文献为示例，实际引用时需核对具体论文信息。)
**Background of BIRC6 Antibody**
BIRC6 (baculoviral IAP repeat-containing protein 6), also known as Apollon, is a member of the inhibitor of apoptosis (IAP) family, characterized by its unique structure containing baculovirus IAP repeat (BIR) domains and a ubiquitin-associated (UBA) domain. It is the largest IAP protein, encoded by the *BIRC6* gene, and plays a dual role in regulating apoptosis and protein ubiquitination. BIRC6 inhibits caspase-dependent apoptosis by binding to and neutralizing caspases-3. -7. and -9. while its E3 ubiquitin ligase activity promotes proteasomal degradation of pro-apoptotic factors like Smac/DIABLO.
BIRC6 is critical in maintaining cellular survival, particularly in cancer cells, where its overexpression is linked to tumor progression, therapeutic resistance, and poor prognosis. It is also implicated in neurodegenerative diseases, where its dysregulation may contribute to neuronal death.
BIRC6 antibodies are essential tools for studying these mechanisms. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect BIRC6 expression levels, subcellular localization, and interactions in tissues or cell lines. High-quality BIRC6 antibodies exhibit specificity for distinct epitopes within the protein, enabling researchers to explore its functional roles or validate its as a therapeutic target. However, variability in antibody performance (e.g., cross-reactivity) requires careful validation for experimental accuracy. Research on BIRC6 continues to focus on its potential as a biomarker or target in cancer therapy and neurodegenerative disorders.
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