Rabbit Polyclonal FAM125A(N-Term) Antibody

The FAM125A (N-Term) antibody is a monoclonal or polyclonal reagent designed to target the N-terminal region of FAM125A (Family With Sequence Similarity 125 Member A), a protein encoded by the FAM125A gene. Also known as KIAA1705. FAM125A is a member of the FAM125 family and is primarily localized in the cytoplasm. It contains a conserved BAR (Bin/Amphiphysin/Rvs) domain in its N-terminus, suggesting potential roles in membrane curvature sensing, cytoskeletal organization, or intracellular trafficking. The antibody is commonly used in techniques like Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to detect FAM125A expression in human, mouse, or rat tissues and cell lines. Its specificity for the N-terminal region helps distinguish FAM125A from homologous proteins, minimizing cross-reactivity. Research indicates FAM125A may interact with cytoskeletal components or signaling molecules, though its precise biological functions remain under investigation. Studies using this antibody have explored its involvement in neuronal development, cancer progression, or neurodegenerative disorders. For example, altered FAM125A expression has been observed in certain tumors or brain tissues, implicating it in disease mechanisms. The FAM125A (N-Term) antibody serves as a critical tool for elucidating the protein's localization, interactions, and physiological relevance. Commercial versions often include validation data (e.g., knockout controls) to ensure reliability. Further research is needed to fully define FAM125A's molecular pathways and therapeutic potential.