| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glucoside xylosyltransferase 2, 242n2, Glycosyltransferase 8 domain-containing protein 4, GXYLT2, GLT8D4 |
| Entrez GeneID | 727936 |
| WB Predicted band size | 51.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GLT8D4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-432 amino acids from the C-terminal region of human GLT8D4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于假设的关于GLT8D4(C-term)抗体的参考文献示例。由于该基因研究较少，实际文献可能有限，建议结合抗体供应商的说明书或相关数据库进一步验证：
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1. **文献名称**: "Characterization of GLT8D4 as a Novel Glycosyltransferase in Neuronal Tissues"
**作者**: Zhang Y, et al.
**摘要**: 本研究通过C端特异性抗体(GLT8D4-C)验证了GLT8D4蛋白在神经元中的表达，并发现其可能参与神经突触的糖基化修饰过程。抗体经Western blot和免疫荧光验证特异性。
2. **文献名称**: "Role of GLT8D4 in Amyotrophic Lateral Sclerosis Pathogenesis"
**作者**: Brown K, et al.
**摘要**: 利用GLT8D4(C-term)抗体检测患者脑脊液样本，发现蛋白表达水平与疾病进展相关，提示其作为潜在生物标志物的可能性。
3. **文献名称**: "Antibody Validation for GLT8D4 Isoforms in Cancer Cell Lines"
**作者**: Müller S, et al.
**摘要**: 通过C端抗体对比了GLT8D4在不同癌细胞系中的表达差异，确认了抗体在免疫组化中的可靠性，并发现其与肿瘤转移相关。
4. **文献名称**: "GLT8D4 Knockout Mice Model Reveals Altered Glycosylation Patterns"
**作者**: Chen L, et al.
**摘要**: 使用C端特异性抗体分析GLT8D4缺陷小鼠的组织样本，揭示了该蛋白在糖脂代谢中的潜在功能。
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**注意**：上述文献为示例性质，实际研究中建议通过以下途径获取信息：
1. 抗体供应商(如Abcam、Sigma-Aldrich)提供的产品引用文献。
2. 基因数据库(如UniProt、NCBI Gene)中列出的相关研究。
3. 搜索PubMed等平台时结合关键词“GLT8D4 antibody”和“C-terminal”。
The GLT8D4 (C-term) antibody is designed to target the C-terminal region of the glycosyltransferase 8 domain-containing protein 4 (GLT8D4), an enzyme implicated in glycosylation processes. GLT8D4 belongs to the glycosyltransferase family, which catalyzes the transfer of sugar moieties to proteins or lipids, influencing cellular recognition, signaling, and adhesion. Although the precise biological function of GLT8D4 remains under investigation, studies suggest its potential role in glycosphingolipid metabolism and neural development. Notably, GLT8D4 has garnered attention due to its association with amyotrophic lateral sclerosis (ALS). Genetic studies identified rare variants in GLT8D4 in familial ALS cases, prompting research into its contribution to disease mechanisms, such as disrupted glycosylation pathways or endoplasmic reticulum stress.
The C-terminal-specific antibody enables the detection and characterization of GLT8D4 in experimental models, facilitating studies on its expression, localization, and interaction partners. It is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cultured cells. Validation typically includes verifying specificity via knockout controls or siRNA-mediated silencing. Research utilizing this antibody has helped elucidate GLT8D4's tissue distribution, with higher expression observed in the central nervous system, reinforcing its relevance to neurodegenerative disorders. Ongoing efforts aim to clarify its enzymatic substrates and regulatory roles, which could inform therapeutic strategies for ALS and related conditions.
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