| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dentin sialophosphoprotein, Dentin phosphoprotein, Dentin phosphophoryn, DPP, Dentin sialoprotein, DSP, DSPP |
| Entrez GeneID | 1834 |
| WB Predicted band size | 131.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DSPP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-76 amino acids of human DSPP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于DSPP(N-term)抗体的3篇参考文献示例(注：文献为虚拟构造，仅供格式参考)：
1. **标题**: *Dentin sialophosphoprotein (DSPP) N-terminal antibodies reveal spatial expression during tooth development*
**作者**: Smith A, et al.
**摘要**: 本研究利用DSPP N端特异性抗体，通过免疫组化分析小鼠牙齿发育过程，发现DSPP前体蛋白在成牙本质细胞中高表达，并参与细胞外基质的早期矿化调控。
2. **标题**: *Characterization of DSPP proteolytic processing using N-terminal specific antibodies*
**作者**: Lee B, et al.
**摘要**: 通过Western blot和质谱分析，验证DSPP N端抗体可特异性识别未裂解的全长蛋白及N端片段(DSP)，揭示DSPP在分泌后经历酶解加工的功能分化。
3. **标题**: *DSPP mutations and dentinogenesis imperfecta: N-terminal antibody-based diagnosis*
**作者**: Chen X, et al.
**摘要**: 研究利用DSPP N端抗体检测遗传性牙本质发育不全(DGI)患者样本，发现突变导致DSPP蛋白异常截短，抗体可作为临床诊断工具辅助基因检测。
如需真实文献，建议通过PubMed或Google Scholar检索关键词“DSPP N-terminal antibody”或“DSPP antibody dentin”。
Dentin sialophosphoprotein (DSPP) is a critical extracellular matrix protein predominantly expressed in dentin, playing a vital role in tooth development and mineralization. It is synthesized as a precursor protein that undergoes proteolytic cleavage to generate two functional fragments: dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). The N-terminal region of DSPP corresponds to the DSP fragment, which is implicated in cell signaling, odontoblast differentiation, and early dentin matrix organization.
DSPP (N-term) antibodies are specifically designed to target the N-terminal region of DSPP, enabling researchers to study its expression, localization, and function in dental tissues. These antibodies are widely used in immunohistochemistry, Western blotting, and immunofluorescence to investigate DSPP processing, dentinogenesis mechanisms, and pathological conditions such as dentinogenesis imperfecta (DGI) and dentin dysplasia. Mutations in the DSPP gene are closely associated with these hereditary dentin defects, making DSPP (N-term) antibodies valuable tools for diagnostic and functional studies.
Additionally, these antibodies contribute to research on tooth regeneration and repair, offering insights into DSPP's role in signaling pathways and interactions with other matrix components. Their specificity ensures accurate detection of DSPP isoforms, aiding in the exploration of developmental biology and genetic disorders affecting mineralized tissues.
×
