Rabbit Polyclonal INTS3 Antibody

The INTS3 antibody is a tool used to detect the INTS3 protein, a key component of the Integrator Complex (IC), a multi-subunit complex associated with RNA polymerase II (Pol II). The IC plays diverse roles in RNA processing, including the 3'-end maturation of small nuclear RNAs (snRNAs) and regulating the transcription of specific genes. INTS3 (Integrator Complex Subunit 3) contains a conserved PCI (Proteasome, COP9. Initiation factor 3) domain, suggesting involvement in protein-protein interactions. Beyond RNA processing, INTS3 is implicated in the DNA damage response (DDR) pathway. It interacts with other DDR proteins, such as ASUN and NABP2. to maintain genomic stability, particularly in resolving replication stress and repairing double-strand breaks. Dysregulation of INTS3 has been linked to developmental disorders and cancers. For example, mutations or reduced INTS3 expression correlate with poor prognosis in certain malignancies, possibly due to impaired DNA repair mechanisms. The INTS3 antibody is widely used in research to study its cellular localization, expression levels, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Its role in bridging RNA metabolism and genome stability makes it a molecule of interest in understanding cancer biology and cellular stress responses.