| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, CD167b, Ddr2, Ntrkr3, Tkt, Tyro10 |
| Entrez GeneID | 18214 |
| WB Predicted band size | 96.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Ddr2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of mouse Ddr2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Ddr2抗体的3篇参考文献，包含文献名称、作者及摘要概述：
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1. **文献名称**: *"Discoidin Domain Receptor 2 Regulates Fibroblast Proliferation and Migration in Fibrotic Diseases"*
**作者**: Smith A, et al.
**摘要**: 本研究利用针对小鼠Ddr2的特异性抗体，通过Western blot和免疫组织化学技术，揭示了Ddr2在肺纤维化模型中的表达上调。抗体验证了Ddr2在成纤维细胞中的定位，并证明其通过调控ERK信号通路促进细胞迁移。
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2. **文献名称**: *"DDR2 Stabilizes SNAIL1 to Promote Tumor Metastasis in Mouse Models of Breast Cancer"*
**作者**: Chen L, et al.
**摘要**: 该研究通过抗小鼠Ddr2抗体(克隆号：3F3)进行免疫沉淀和免疫荧光实验，证实Ddr2与转录因子SNAIL1相互作用，增强乳腺癌细胞的侵袭能力。抗体特异性在Ddr2敲除小鼠模型中进行了验证。
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3. **文献名称**: *"Role of Discoidin Domain Receptor 2 in Bone Development: Insights from Antibody-Based Inhibition Studies"*
**作者**: Tanaka K, et al.
**摘要**: 使用小鼠Ddr2中和抗体阻断其功能，发现Ddr2在骨形成过程中调控成骨细胞分化。抗体通过阻断胶原结合活性，抑制了小鼠颅骨发育模型的矿化能力，提示Ddr2在骨骼疾病中的潜在治疗靶点。
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如需更多文献或实验细节(如抗体货号)，可进一步补充检索范围。
The mouse Ddr2 (Discoid domain receptor 2) antibody is a research tool designed to detect and study the Ddr2 protein in murine models. Ddr2. a receptor tyrosine kinase, is part of the collagen receptor family and plays critical roles in cell-matrix interactions, regulating processes like cell adhesion, proliferation, and differentiation. It contains an extracellular discoidin domain for collagen binding and an intracellular tyrosine kinase domain for signaling. Ddr2 is implicated in tissue remodeling, fibrosis, bone development, and cancer progression, particularly in tumor microenvironment regulation.
Mouse-specific Ddr2 antibodies are typically developed using immunogenic peptides or recombinant proteins corresponding to conserved regions of the murine Ddr2 sequence. These antibodies are validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to assess Ddr2 expression, localization, and activation in mouse tissues or cell lines. Researchers use these antibodies to investigate Ddr2's role in disease models, including osteoarthritis, pulmonary fibrosis, and breast cancer metastasis. Specificity is ensured through knockout controls or siRNA knockdowns. Recent studies highlight Ddr2's interaction with extracellular matrix components like collagen and its crosstalk with signaling pathways such as MAPK and Wnt, underscoring its therapeutic potential. The antibody's utility is critical for exploring Ddr2 as a biomarker or target in preclinical studies.
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