Rabbit Polyclonal DBN1 Antibody

The DBN1 (Drebrin-like protein) antibody is a research tool targeting the DBN1 protein, a member of the actin-binding ADF-H domain family. DBN1 plays a critical role in cytoskeletal dynamics, particularly in regulating actin filament assembly and disassembly, which is essential for processes like cell motility, synaptic plasticity, and cytokinesis. It is highly expressed in neurons and immune cells, implicating its involvement in neurological functions and immune responses. Dysregulation of DBN1 has been linked to diseases such as Alzheimer’s, cancer metastasis, and immunological disorders. The DBN1 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and interactions in cellular and tissue contexts. Researchers also employ it to explore DBN1’s role in pathological mechanisms, including tumor invasiveness or neurodegenerative protein aggregation. Commercial DBN1 antibodies are typically validated for specificity against conserved epitopes, often in human, mouse, or rat models. However, variability in isoform detection (e.g., DBN1-A vs. DBN1-B) requires careful antibody selection. Its utility spans basic cell biology, neuroscience, and clinical research, particularly in biomarker discovery for cancer prognosis or neurological disease monitoring.