| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76, LCP2 |
| Entrez GeneID | 3937 |
| WB Predicted band size | 60.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LCP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 303-337 amino acids from the Central region of human LCP2. |
+ +
以下是关于LCP2(SLP-76)抗体的3篇参考文献及其摘要概括：
---
1. **文献名称**：*SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells*
**作者**：S. M. Hernández-Hansen et al.
**摘要**：本研究利用LCP2(SLP-76)特异性抗体，通过Western blot和免疫沉淀技术，揭示了SLP-76在肥大细胞高亲和力IgE受体(FcεRI)信号传导中的关键作用。敲除SLP-76显著抑制了肥大细胞脱颗粒和炎症介质的释放。
---
2. **文献名称**：*The role of SLP-76 in platelet and T-cell function: Insights from antibody-based studies*
**作者**：L. E. Sommers et al.
**摘要**：通过抗LCP2抗体阻断实验，发现SLP-76在血小板聚集和T细胞受体(TCR)信号通路中不可或缺。研究证实，SLP-76抗体抑制了PLCγ1磷酸化和钙离子动员，影响免疫应答和血栓形成。
---
3. **文献名称**：*SLP-76 expression correlates with disease severity in rheumatoid arthritis*
**作者**：K. M. Murphy et al.
**摘要**：采用LCP2抗体对类风湿关节炎(RA)患者滑膜组织进行免疫组化分析，发现SLP-76表达水平与炎症程度正相关，提示其可作为潜在治疗靶点或疾病活动性生物标志物。
---
如需更多文献或特定研究方向，可进一步补充关键词检索。
Lymphocyte Cytosolic Protein 2 (LCP2), also known as SLP-76 (SH2 domain-containing leukocyte protein of 76 kDa), is a critical adaptor protein involved in intracellular signaling pathways of immune cells. Primarily expressed in hematopoietic cells, LCP2 plays a pivotal role in T-cell receptor (TCR) and B-cell receptor (BCR) signaling by facilitating interactions between membrane receptors, kinases, and downstream effectors. It coordinates immune responses by regulating processes like cell activation, proliferation, and cytokine production through its modular domains (SH2. proline-rich, and tyrosine-rich regions).
LCP2 antibodies are essential tools for studying immune cell signaling and dysfunction. They enable detection, quantification, and functional analysis of LCP2 in experimental models, including Western blotting, immunofluorescence, and flow cytometry. Dysregulation of LCP2 has been implicated in immune disorders, such as immunodeficiency syndromes and autoimmune diseases, as well as hematologic malignancies like T-cell lymphomas. Research using LCP2 antibodies has advanced understanding of immune pathologies and potential therapeutic targets. However, variability in antibody specificity across commercial sources necessitates careful validation to ensure experimental reproducibility. Ongoing studies continue to explore LCP2's role in immune regulation and its interplay with other signaling molecules.
×
