Rabbit Polyclonal NISCH(N-Term) Antibody

The NISCH (N-Term) antibody targets the N-terminal region of Nischarin, a protein encoded by the *NISCH* gene. Nischarin, also known as imidazoline receptor antisera-selected protein (IRAS), functions as a scaffolding protein involved in diverse cellular processes, including cell migration, adhesion, and receptor trafficking. It interacts with integrins, Ras-related proteins, and neurotransmitter receptors, modulating signaling pathways such as the PI3K/AKT and Rac1 pathways. Its role in tumor suppression has been highlighted, as it inhibits breast cancer progression by regulating cell invasion and metastasis. The N-terminal domain is critical for mediating these interactions, particularly in binding to cytoplasmic partners and influencing cytoskeletal dynamics. Antibodies specific to the N-Term region are essential tools for studying Nischarin's expression, localization, and molecular interactions in models of cancer, neurological disorders, and metabolic diseases. They are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to elucidate Nischarin's functional mechanisms. Research utilizing this antibody has contributed to understanding its tumor-suppressive effects and potential therapeutic applications, though its broader physiological roles remain under investigation.