Rabbit Polyclonal DANREhoxb8b Antibody

The DANRE Hoxb8b antibody is a tool developed to study the Hoxb8b protein in *Danio rerio* (zebrafish). Hox genes, highly conserved across vertebrates, encode transcription factors critical for anterior-posterior body axis patterning and segmental identity during embryonic development. In zebrafish, Hoxb8b belongs to the HoxB cluster and is implicated in neural crest cell migration, fin development, and somitogenesis. The antibody is typically generated by immunizing animals (e.g., rabbits or mice) with a synthetic peptide or recombinant protein corresponding to a specific epitope of the zebrafish Hoxb8b protein. It enables detection of endogenous Hoxb8b expression via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Researchers use this antibody to explore spatial-temporal expression patterns, gene function in knockout/morphant models, and regulatory mechanisms in developmental processes. Its specificity is validated through controls like pre-immune serum comparison or knockdown validation. The DANRE Hoxb8b antibody has contributed to studies on evolutionary conservation of Hox gene function, particularly in teleosts, and insights into developmental disorders linked to Hox dysregulation. Commercial suppliers often provide detailed protocols and validation data to ensure reproducibility in diverse experimental settings.