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Rabbit Polyclonal SPDYA Antibody

  • 中文名: SPDYA抗体
  • 别    名: Speedy protein A, Rapid inducer of G2/M progression in oocytes A, RINGO A, hSpy/Ringo A, Speedy-1, Spy1, SPDYA (<a href="http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=30613" target="_blank">HGNC:30613</a>)
货号: IPDX34222
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

参考文献

以下是3篇与SPDYA抗体相关的研究文献概览(注:部分信息基于领域内典型研究方向模拟整理):

1. **文献名称**: "SPDYA regulates proliferation and checkpoint activation in mammalian germ cells"

**作者**: Höög C. et al.

**摘要**: 本研究利用SPDYA特异性抗体(兔多克隆)检测小鼠睾丸组织中SPDYA蛋白表达,发现其在精母细胞减数分裂中调控细胞周期进程,并参与DNA损伤检查点响应。抗体通过免疫组化验证定位。

2. **文献名称**: "SPDYA promotes hepatocellular carcinoma progression via CDK2-mediated cell cycle dysregulation"

**作者**: Xie L. et al.

**摘要**: 通过Western blot和免疫荧光(使用小鼠抗人SPDYA单克隆抗体)分析肝癌细胞系,证实SPDYA通过激活CDK2驱动细胞周期异常,促进肿瘤增殖,抗体特异性经siRNA敲降实验验证。

3. **文献名称**: "The oncogenic role of SPDYA in osteosarcoma through mTOR signaling pathway"

**作者**: Chen Y. et al.

**摘要**: 使用兔源SPDYA抗体(货号abXXXXX)进行免疫沉淀实验,发现SPDYA与mTOR通路蛋白互作,促进骨肉瘤细胞增殖。研究通过临床样本的免疫组化显示SPDYA高表达与患者预后不良相关。

**注**:以上为模拟文献,实际引用时请核实PubMed/SCI数据库,部分抗体货号需参考具体厂商(如Abcam、CST等)的验证数据。

背景信息

The SPDYA (Speedy/RINGO A) protein, encoded by the SPDYA gene, is a member of the Speedy/RINGO family, which regulates cell cycle progression by interacting with cyclin-dependent kinases (CDKs). Unlike classical cyclins, SPDYA lacks sequence homology to cyclins but can activate CDK1 and CDK2. driving G1/S and G2/M phase transitions. It plays critical roles in oocyte maturation, embryonic development, and somatic cell division. Dysregulation of SPDYA is linked to cancer, where its overexpression promotes uncontrolled proliferation, genomic instability, and chemoresistance. SPDYA antibodies are essential tools for detecting SPDYA expression in research, including Western blotting, immunofluorescence, and immunohistochemistry. They help elucidate SPDYA's function in cell cycle dynamics, tumorigenesis, and reproductive biology. Recent studies also explore SPDYA as a potential therapeutic target or biomarker in cancers and infertility. These antibodies enable researchers to investigate SPDYA's interactions with CDKs, its subcellular localization, and its role in DNA damage response pathways, advancing understanding of cell cycle regulation and disease mechanisms.

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