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Rabbit Polyclonal CHTF8 Antibody

  • 中文名: CHTF8抗体
  • 别    名: Chromosome transmission fidelity protein 8 homolog isoform 2, Decreased expression in renal and prostate cancer protein, CHTF8, DERPC
货号: IPDX34182
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesChromosome transmission fidelity protein 8 homolog isoform 2, Decreased expression in renal and prostate cancer protein, CHTF8, DERPC
WB Predicted band size51.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CHTF8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 344-377 amino acids from human CHTF8.

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参考文献

以下是关于CHTF8抗体的示例参考文献(注:以下内容为虚构示例,仅作格式参考):

1. **文献名称**: "CHTF8 Antibody Characterization in DNA Replication Studies"

**作者**: Smith A, et al.

**摘要**: 本研究开发了一种高特异性的CHTF8多克隆抗体,用于检测其在DNA复制复合体中的定位。通过免疫印迹和免疫荧光实验,证实CHTF8与RFC-like复合体相互作用,参与复制叉的稳定性维持。

2. **文献名称**: "Role of CHTF8 in Chromosome Segregation Revealed by Antibody-Based Knockdown"

**作者**: Lee B, et al.

**摘要**: 利用CHTF8抗体进行免疫沉淀和RNA干扰实验,发现CHTF8缺失导致姐妹染色单体分离异常,提示其在有丝分裂中调控染色体传输的作用。

3. **文献名称**: "CHTF8 Expression Profiling in Cancer Using a Novel Monoclonal Antibody"

**作者**: Chen X, et al.

**摘要**: 报道了一种新型CHTF8单克隆抗体的制备及验证,并用于分析多种癌症组织中CHTF8的表达水平升高,提示其作为潜在肿瘤标志物的可能性。

4. **文献名称**: "Structural Insights into the Ctf18-RFC Complex via CHTF8-Specific Antibody Staining"

**作者**: Tanaka K, et al.

**摘要**: 通过CHTF8抗体的共聚焦显微镜成像,揭示了Ctf18-RFC复合体在DNA损伤修复中的动态组装过程,强调了CHTF8在维持基因组完整性中的关键作用。

(注:若需真实文献,建议通过PubMed或Google Scholar以“CHTF8 antibody”“Ctf8 antibody”等关键词检索。)

背景信息

The CHTF8 (Chromatin Target of PRMT1-associated Factor 8) antibody is a tool used to study the CHTF8 protein, a component of the chromatin remodeling complex involved in DNA replication and repair. CHTF8. also known as CHTF8/And-1. plays a critical role in maintaining genomic stability by facilitating the loading of the DNA polymerase α-primase complex onto chromatin during replication. It interacts with replication proteins like TIMELESS and TIPIN to ensure proper replication fork progression and checkpoint signaling. Dysregulation of CHTF8 has been linked to replication stress, chromosomal instability, and cancer progression. The CHTF8 antibody is commonly employed in research applications such as Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and interactions in cellular contexts. It has been particularly useful in studies exploring replication stress responses, carcinogenesis, and the molecular mechanisms of DNA damage tolerance. Developed in various host species (e.g., rabbit, mouse), this antibody has been validated in multiple cell lines and tissue samples, making it a valuable reagent for understanding replication-associated chromatin dynamics and developing potential therapeutic strategies targeting replication fidelity in diseases.

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