| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cysteine/serine-rich nuclear protein 1, CSRNP-1, Axin-1 up-regulated gene 1 protein, Protein URAX1, TGF-beta-induced apoptosis protein 3, TAIP-3, CSRNP1, AXUD1, TAIP3 |
| Entrez GeneID | 64651 |
| WB Predicted band size | 63.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CSRNP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 501-533 amino acids from human CSRNP1. |
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以下是3条关于CSRNP1抗体的参考文献示例(注：文献信息为模拟生成，实际引用需核实)：
1. **文献名称**：*CSRNP1 promotes apoptosis through interaction with the Wnt/β-catenin pathway*
**作者**：Li, Y. et al.
**摘要**：本研究利用抗CSRNP1抗体进行免疫共沉淀和Western blot分析，发现CSRNP1通过抑制β-catenin活性增强细胞凋亡，为结肠癌治疗提供潜在靶点。
2. **文献名称**：*Development and validation of a specific polyclonal antibody for detecting CSRNP1 in human tissues*
**作者**：Smith, J.R. & Gonzalez, A.
**摘要**：文章描述了一种兔源多克隆抗体的制备与验证，该抗体可特异性识别CSRNP1蛋白，适用于免疫组化(IHC)和免疫荧光(IF)，并在多种癌症组织中检测到CSRNP1表达下调。
3. **文献名称**：*CSRNP1 as a prognostic marker in breast cancer: Insights from antibody-based profiling*
**作者**：Wang, H. et al.
**摘要**：通过抗CSRNP1抗体的免疫组化分析乳腺癌样本，发现CSRNP1低表达与患者不良预后显著相关，提示其可能作为乳腺癌的生物标志物。
(如需具体文献，建议在PubMed或Google Scholar中检索“CSRNP1 antibody”及相关研究主题。)
The cysteine-serine-rich nuclear protein 1 (CSRNP1), also known as Axin1 up-regulated 1 (AXUD1), is a member of the CSRNP family of transcription factors that play roles in apoptosis, cell proliferation, and stress responses. CSRNP1 contains conserved cysteine-serine-rich domains and nuclear localization signals, enabling its function in transcriptional regulation. Studies suggest it acts as a pro-apoptotic factor by interacting with components of the Wnt/β-catenin and MAPK signaling pathways, influencing gene expression linked to cell survival and differentiation.
CSRNP1 antibodies are immunological tools developed to detect and quantify CSRNP1 protein expression in research applications. These antibodies are typically validated for techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Their specificity is critical for investigating CSRNP1's role in physiological and pathological contexts, such as cancer, where its expression is often downregulated in tumors, correlating with poor prognosis. Additionally, CSRNP1 has been implicated in immune regulation and neurodevelopment, making its antibodies valuable for studying these processes.
Available as polyclonal or monoclonal formats, CSRNP1 antibodies are raised in hosts like rabbits or mice using immunogenic peptide sequences. Proper validation ensures minimal cross-reactivity with other CSRNP family members (CSRNP2. CSRNP3). Researchers utilize these antibodies to explore CSRNP1's interaction networks, subcellular localization, and involvement in diseases, aiding the development of therapeutic strategies targeting its pathways.
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