Rabbit Polyclonal GNG3 Antibody

The GNG3 antibody targets the gamma-3 subunit of heterotrimeric G proteins, which are critical for intracellular signal transduction. G proteins, composed of α, β, and γ subunits, relay extracellular signals via G protein-coupled receptors (GPCRs) to regulate downstream effectors. The GNG3-encoded γ3 subunit combines with a β subunit to form the stable Gβγ dimer, which modulates diverse pathways, including ion channel activity, enzyme activation, and cell proliferation. GNG3 is ubiquitously expressed but shows tissue-specific roles, with studies implicating it in neuronal development, hormone secretion, and cancer progression. For instance, elevated GNG3 expression correlates with tumor growth and metastasis in certain cancers. Antibodies against GNG3 are essential tools for studying its expression, localization, and interactions in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to investigate G protein signaling mechanisms. Validated GNG3 antibodies help elucidate its role in diseases, offering potential insights into therapeutic targeting of GPCR pathways. Specificity and validation (e.g., knockout controls) are critical, as γ subunits share structural homology. Research using GNG3 antibodies continues to expand understanding of cellular signaling networks and their dysregulation in human diseases.