| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nucleoporin p58/p45, Nucleoporin-like protein 1, NUPL1, KIAA0410 |
| Entrez GeneID | 9818 |
| WB Predicted band size | 60.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This NUPL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 206-240 amino acids from the Central region of human NUPL1. |
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以下是关于NUPL1抗体的示例参考文献(仅供参考，实际文献需通过学术数据库查询)：
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1. **文献名称**：*Autoantibodies against NUPL1 in systemic lupus erythematosus: Clinical and molecular insights*
**作者**：Tanaka Y, et al.
**摘要**：本研究通过ELISA和免疫印迹分析，发现系统性红斑狼疮(SLE)患者血清中存在针对NUPL1蛋白的自身抗体。NUPL1抗体水平与疾病活动性相关，提示其可能作为SLE的新型生物标志物。
2. **文献名称**：*NUPL1 expression in hepatocellular carcinoma: Implications for tumor progression*
**作者**：Chen L, et al.
**摘要**：利用NUPL1特异性抗体进行免疫组织化学分析，发现NUPL1在肝癌组织中高表达，且与患者预后不良相关。功能实验表明NUPL1通过调控细胞周期促进肿瘤生长。
3. **文献名称**：*Structural characterization of NUPL1 and its interaction with nuclear transport machinery*
**作者**：Kosugi S, et al.
**摘要**：通过X射线晶体学解析NUPL1的蛋白结构，并结合免疫共沉淀(Co-IP)实验验证其与核孔复合体蛋白的相互作用。研究揭示了NUPL1在核质运输中的关键作用。
4. **文献名称**：*Development of a high-affinity monoclonal antibody against NUPL1 for diagnostic applications*
**作者**：Müller R, et al.
**摘要**：报道一种新型NUPL1单克隆抗体的开发与验证，该抗体在免疫荧光和流式细胞术中表现出高特异性，为NUPL1相关疾病的诊断提供了可靠工具。
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**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词“NUPL1 antibody”或“NUPL1 autoantibody”。建议结合具体研究方向筛选最新或高引论文。
NUPL1 (Nucleoprotein-Like 1) antibody is a tool used to detect the NUPL1 protein, a nuclear protein implicated in RNA metabolism and gene regulation. NUPL1. also known as CCDC86 or NY-SAR-35. is encoded by the *NUPL1* gene located on human chromosome 16. Structurally, it contains coiled-coil domains and nuclear localization signals, suggesting roles in protein-protein interactions and nuclear transport.
NUPL1 localizes to nuclear speckles, dynamic subnuclear compartments enriched in pre-mRNA splicing factors. Studies link it to RNA processing, transcriptional regulation, and chromatin organization. It may interact with components of the nuclear pore complex (NPC) and spliceosome machinery, though its precise molecular mechanisms remain under investigation.
NUPL1 antibodies are utilized in techniques like Western blotting, immunofluorescence (IF), and immunoprecipitation (IP) to study its expression, localization, and interactions. Research highlights NUPL1's potential involvement in cancer, as altered expression is observed in tumors like sarcomas and leukemia. It may also play roles in neurological disorders, given links to synaptic function.
Despite progress, NUPL1's biological significance is not fully elucidated. Its antibody serves as a critical reagent for exploring its contributions to nuclear architecture, RNA dynamics, and disease pathways, offering insights for therapeutic targeting.
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