Rabbit Polyclonal RGS19(S24) Antibody

The RGS19 (S24) antibody is a specialized tool used to detect Regulator of G-protein Signaling 19 (RGS19), a protein involved in modulating G-protein-coupled receptor (GPCR) signaling pathways. RGS19. also known as GAIP (G Alpha Interacting Protein), belongs to the RGS protein family, which negatively regulates G-protein signaling by accelerating GTPase activity of Gα subunits, thereby terminating downstream signaling. The "S24" designation typically refers to a specific phosphorylation site (serine at position 24) or a splice variant, though exact epitope details may vary by manufacturer. This antibody is widely used in research to study RGS19's role in cellular processes such as immune regulation, neurotransmitter signaling, and cancer progression, where dysregulated GPCR signaling is implicated. Its applications include Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and post-translational modifications. Studies employing the RGS19 (S24) antibody have contributed to understanding its tumor-suppressive functions in certain cancers and its interaction with oncogenic pathways. Validation typically involves knockout controls or peptide blocking to confirm specificity. Researchers prioritize this antibody for investigating RGS19's context-dependent roles in disease models or signal transduction mechanisms.