Rabbit Polyclonal RNF133 Antibody

The RNF133 antibody is a research tool designed to detect and study the RNF133 protein, a member of the RING finger (Really Interesting New Gene) family characterized by a conserved zinc-binding domain critical for E3 ubiquitin ligase activity. RNF133 is a transmembrane protein localized to the endoplasmic reticulum (ER) and cell membrane, implicated in ubiquitination pathways that regulate protein degradation, cellular signaling, and receptor trafficking. Its role in modulating processes like ER-associated degradation (ERAD) and interactions with signaling receptors (e.g., GPCRs) highlights its potential involvement in diseases such as cancer and neurological disorders. Research using RNF133 antibodies has revealed its expression patterns in various tissues, including the brain and immune cells, and explored its regulatory effects on apoptosis, cell proliferation, and immune responses. Studies also suggest links between RNF133 dysregulation and tumor progression or neurodegenerative conditions, though its exact mechanisms remain under investigation. The antibody is commonly employed in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to validate protein expression, post-translational modifications, and molecular interactions. As an evolving target, RNF133 continues to attract interest for its dual roles in homeostasis and disease, with its antibody serving as a key reagent for unraveling its biological and pathological significance.