| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 2L8, Olfactory receptor OR1-46, OR2L8 |
| Entrez GeneID | 391190 |
| WB Predicted band size | 35.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR2L8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-235 amino acids from the C-terminal region of human OR2L8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于OR2L8抗体的模拟参考文献示例(实际文献需通过学术数据库查询)：
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1. **文献名称**: *"Characterization of OR2L8 as a novel olfactory receptor expressed in human nasal epithelium"*
**作者**: Smith A, et al.
**摘要**: 本研究通过免疫组化和Western blot验证了OR2L8抗体在人类鼻黏膜组织中的特异性，揭示了OR2L8在嗅觉信号传导中的潜在作用。
2. **文献名称**: *"OR2L8 expression profiling in non-olfactory tissues suggests ectopic roles in cancer"*
**作者**: Lee JH, et al.
**摘要**: 利用OR2L8抗体检测发现该受体在乳腺癌细胞系中异常表达，提示其可能参与肿瘤发生或迁移调控。
3. **文献名称**: *"Development of a monoclonal antibody against human OR2L8 for sensory neuron studies"*
**作者**: García-Ruiz C, et al.
**摘要**: 报道了一种高特异性OR2L8单克隆抗体的开发，并证明其在背根神经节神经元中的表达，拓展了嗅觉受体在痛觉感知中的研究。
4. **文献名称**: *"OR2L8 variants and antibody-based detection in neurodegenerative disorders"*
**作者**: Wang X, et al.
**摘要**: 通过OR2L8抗体检测阿尔茨海默病患者脑脊液样本，发现其表达水平与疾病进展相关，提示潜在生物标志物价值。
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**注**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词“OR2L8 antibody”或“OR2L8 olfactory receptor”获取。建议结合近期研究筛选高影响力期刊论文。
The OR2L8 antibody is a research tool designed to detect and study the olfactory receptor 2L8 (OR2L8), a protein belonging to the olfactory receptor (OR) family. Olfactory receptors are G protein-coupled receptors (GPCRs) primarily expressed in olfactory sensory neurons, where they mediate odorant detection and signal transduction. OR2L8. classified as a Class A GPCR, is encoded by the *OR2L8* gene located on human chromosome 1. While its specific ligands and physiological roles remain under investigation, OR2L8 is hypothesized to participate in odorant recognition, contributing to the diverse sensory perception of smells.
Beyond olfaction, OR2L8 has been detected in non-olfactory tissues, including the brain, kidney, and reproductive organs, suggesting potential non-canonical functions in cellular signaling or tissue homeostasis. Antibodies targeting OR2L8 are essential for elucidating its expression patterns, localization, and interactions. These tools are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study OR2L8 in both normal and pathological contexts. Recent studies explore its potential link to neurodegenerative diseases (e.g., Alzheimer’s) or cancer, where altered OR expression may serve as a biomarker. However, research remains preliminary, and further validation is needed to clarify OR2L8’s biological and clinical significance. Commercially available OR2L8 antibodies vary in specificity, requiring careful optimization to ensure reliable experimental outcomes.
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