| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 4M2, Olfactory receptor OR15-3, OR4M2 |
| Entrez GeneID | 390538 |
| WB Predicted band size | 35.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR4M2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-271 amino acids from the C-terminal region of human OR4M2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于OR4M2抗体的假设性参考文献示例(注：OR4M2相关研究较少，以下内容为模拟数据，建议通过PubMed或Google Scholar验证实际文献)：
1. **文献名称**: "Characterization of OR4M2 as a novel biomarker in renal cell carcinoma using a specific polyclonal antibody"
**作者**: Lee S, et al.
**摘要**: 开发了一种针对OR4M2的多克隆抗体，验证其在肾癌细胞系中的高表达，并通过免疫组化证明其与肿瘤分期的相关性。
2. **文献名称**: "OR4M2 antibody-based detection of ectopic olfactory receptors in human vascular smooth muscle cells"
**作者**: Zhang Y, et al.
**摘要**: 利用OR4M2单克隆抗体，首次在血管平滑肌细胞中检测到该受体表达，探讨其可能参与血压调节的分子机制。
3. **文献名称**: "Development of a sensitive ELISA assay for OR4M2 quantification using chicken-derived IgY antibodies"
**作者**: Müller T, et al.
**摘要**: 报道了一种基于鸡源IgY抗体的OR4M2检测方法，灵敏度达pg/mL级别，应用于脑脊液样本中痕量OR4M2的定量分析。
4. **文献名称**: "Cross-reactivity analysis of commercial OR4M2 antibodies reveals unexpected neuronal staining patterns"
**作者**: Gonzalez-Rico PL, et al.
**摘要**: 系统评估了市售OR4M2抗体的特异性，发现部分抗体与未知神经元蛋白存在交叉反应，强调抗体验证的重要性。
**实际检索建议**：
- 使用关键词："OR4M2 antibody"、"anti-OR4M2"、"olfactory receptor 4M2"
- 结合组织特异性词汇(如kidney/cancer/neuronal)缩小范围
- 优先检索近5年文献，因该领域研究较新
The OR4M2 antibody is designed to target the olfactory receptor family 4 subfamily M member 2 (OR4M2), a G protein-coupled receptor (GPCR) primarily associated with olfactory signaling. Olfactory receptors, encoded by the largest gene family in the human genome, detect odorant molecules and initiate signal transduction via cAMP pathways. While OR4M2 is expressed in olfactory sensory neurons, emerging studies suggest its presence in non-olfactory tissues (e.g., brain, kidneys, or testes), hinting at broader physiological roles, such as chemosensation beyond smell, cellular communication, or disease-related processes.
The OR4M2 antibody is typically developed for research applications, including immunohistochemistry, Western blotting, or flow cytometry, to map its expression patterns and investigate its functional mechanisms. Its specificity is validated using knockout controls or recombinant protein assays. Commercial OR4M2 antibodies are often produced in hosts like rabbits or mice, using immunogens derived from conserved regions of the protein. Challenges include potential cross-reactivity due to high homology among olfactory receptor subtypes, necessitating rigorous validation.
Current research focuses on OR4M2’s role in neurological disorders, cancer, or metabolic regulation, leveraging the antibody as a tool to explore its ligand interactions and signaling pathways. However, functional studies remain limited, underscoring the need for further exploration into its physiological and pathological relevance.
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