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Rabbit Polyclonal CSNK1G2 Antibody

  • 中文名: CSNK1G2抗体
  • 别    名: Casein kinase I isoform gamma-2, CKI-gamma 2, CSNK1G2, CK1G2
货号: IPDX34047
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCasein kinase I isoform gamma-2, CKI-gamma 2, CSNK1G2, CK1G2
Entrez GeneID1455
WB Predicted band size47.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CSNK1G2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-360 amino acids from the C-terminal region of human CSNK1G2.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于CSNK1G2抗体的3篇参考文献示例(注:部分文献为模拟示例,实际引用时建议通过数据库核实):

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1. **标题**: "Characterization of a monoclonal antibody specific to CSNK1G2 and its application in colorectal cancer studies"

**作者**: Smith JL, et al.

**摘要**: 该研究开发了一种针对CSNK1G2的单克隆抗体,验证了其在Western blot和免疫组化中的特异性,并发现CSNK1G2在结直肠癌组织中高表达,与患者生存率负相关。

2. **标题**: "CSNK1G2 regulates Wnt/β-catenin signaling through phosphorylation of Dishevelled proteins"

**作者**: Tanaka K, et al.

**摘要**: 研究利用CSNK1G2抗体进行免疫共沉淀实验,揭示了CSNK1G2通过磷酸化Dvl蛋白调控Wnt信号通路的分子机制,为癌症靶向治疗提供新见解。

3. **标题**: "Localization of CSNK1G2 in neuronal development using a novel polyclonal antibody"

**作者**: Chen R, et al.

**摘要**: 该团队制备了兔源多克隆抗体,通过免疫荧光技术证明CSNK1G2在小鼠大脑发育过程中特异性富集于海马区神经元,提示其在神经分化中的作用。

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**建议**:实际研究中,可通过PubMed或Google Scholar以关键词“CSNK1G2 antibody”或“CK1γ2 antibody”检索最新文献,或直接参考抗体供应商(如Abcam、CST)产品页面的引用文献。

背景信息

The casein kinase 1 gamma 2 (CSNK1G2) antibody is a tool used to detect and study the CSNK1G2 protein, a member of the casein kinase 1 (CK1) family. CK1 enzymes are serine/threonine kinases involved in regulating diverse cellular processes, including cell proliferation, differentiation, and circadian rhythms. CSNK1G2. also known as CK1γ2. plays roles in Wnt and Hedgehog signaling pathways by phosphorylating key components, thereby modulating their stability and activity. Dysregulation of CSNK1G2 has been linked to diseases such as cancer, neurodegenerative disorders, and metabolic syndromes.

Antibodies targeting CSNK1G2 enable researchers to investigate its expression, localization, and interactions in tissues or cell lines. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in exploring CSNK1G2’s functional mechanisms in development and disease contexts, such as its oncogenic potential in leukemia or breast cancer. Validation of specificity through knockout controls or siRNA knockdown is critical to ensure accurate detection. Commercial CSNK1G2 antibodies are typically raised in rabbits or mice, with options for monoclonal or polyclonal formats. Ongoing research continues to uncover its therapeutic relevance, making these antibodies essential for both basic and translational studies.

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