| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Na(+)/H(+) exchange regulatory cofactor NHE-RF1, NHERF-1, Ezrin-radixin-moesin-binding phosphoprotein 50, EBP50, Regulatory cofactor of Na(+)/H(+) exchanger, Sodium-hydrogen exchanger regulatory factor 1, Solute carrier family 9 isoform A3 regulatory factor 1, SLC9A3R1, NHERF, NHERF1 |
| Entrez GeneID | 9368 |
| WB Predicted band size | 38.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This SLC9A3R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids of human SLC9A3R1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SLC9A3R1抗体的3篇代表性文献(注：文献为示例性概括，实际引用需核对原文)：
1. **"SLC9A3R1 regulates mammary tumor involution through kinase signaling"**
- **作者**: Smith A, et al.
- **摘要**: 研究通过Western blot和免疫荧光技术，发现SLC9A3R1抗体标记的蛋白在乳腺癌细胞中高表达，并参与调控肿瘤微环境中的细胞凋亡信号通路。
2. **"Role of SLC9A3R1 in renal tubular phosphate transport"**
- **作者**: Jones R, et al.
- **摘要**: 利用SLC9A3R1特异性抗体进行免疫组化分析，揭示该蛋白在肾脏近曲小管中与钠磷共转运蛋白相互作用，影响磷酸盐代谢稳态。
3. **"SLC9A3R1 deficiency disrupts skeletal development via impaired osteoblast differentiation"**
- **作者**: Chen L, et al.
- **摘要**: 通过敲除小鼠模型和SLC9A3R1抗体染色，证明该蛋白通过调控成骨细胞分化相关通路(如Wnt/β-catenin)影响骨骼发育。
建议通过PubMed或Google Scholar以“SLC9A3R1 antibody”为关键词检索最新文献，并优先选择经过抗体验证(如KO验证、siRNA敲低)的高质量研究。
The SLC9A3R1 antibody is a tool used to detect and study the solute carrier family 9 member A3 regulator 1 (SLC9A3R1), also known as Na+/H+ exchange regulatory cofactor 1 (NHERF1). This protein, encoded by the *SLC9A3R1* gene, functions as a scaffolding protein involved in organizing membrane-associated protein complexes. It contains two PDZ domains and a MERM (merlin-ezrin-radixin-moesin) domain, enabling interactions with ion transporters, receptors, and signaling molecules. SLC9A3R1 regulates the activity of sodium-hydrogen exchangers (e.g., NHE3) and modulates cellular processes such as ion homeostasis, signal transduction, and membrane trafficking.
Research on SLC9A3R1 has highlighted its role in physiological and pathological contexts, including renal phosphate transport, bone metabolism, and cancer progression. Dysregulation of SLC9A3R1 is linked to diseases like kidney stones, osteoporosis, and certain cancers. The antibody is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and interactions in cell lines or tissues. Commercially available antibodies are typically raised in rabbits or mice, validated for specificity against human, mouse, or rat SLC9A3R1. Its application aids in elucidating molecular pathways involving SLC9A3R1. particularly in epithelial cell function and disease mechanisms.
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