| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, AGAP-2, Centaurin-gamma-1, Cnt-g1, GTP-binding and GTPase-activating protein 2, GGAP2, Phosphatidylinositol 3-kinase enhancer, PIKE, AGAP2, CENTG1, KIAA0167 |
| Entrez GeneID | 116986 |
| WB Predicted band size | 124.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This CENTG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇关于CENTG1抗体的示例文献(虚构内容，仅作格式参考)：
1. **文献名称**：Structural characterization of CENTG1 using monoclonal antibodies
**作者**：Zhang L, et al.
**摘要**：开发了高特异性CENTG1单克隆抗体，通过X射线晶体学解析了CENTG1蛋白的PH结构域与抗体复合物的三维结构，揭示了其与Arf1蛋白互作的分子基础。
2. **文献名称**：CENTG1 expression profiling in glioblastoma via immunohistochemistry
**作者**：Kim S, et al.
**摘要**：利用兔源多克隆CENTG1抗体对胶质母细胞瘤组织进行免疫组化分析，发现CENTG1在肿瘤边缘区高表达，并与EGFR信号通路激活呈正相关。
3. **文献名称**：Development of phospho-specific CENTG1 antibody for kinase studies
**作者**：Martinez R, et al.
**摘要**：针对CENTG1蛋白的Ser-209磷酸化位点开发了特异性抗体，证实Akt激酶介导的该位点磷酸化可增强CENTG1的GAP活性，影响细胞迁移。
注：以上文献为模拟生成，实际引用请通过PubMed/Google Scholar以"CENTG1 antibody"或"AGAP1 antibody"为关键词检索。
The CENTG1 antibody targets the protein encoded by the CENTG1 gene, also known as AGAP1 (ArfGAP with GTPase domain, ANK repeat, and PH domain 1). This protein belongs to the ArfGAP family, which regulates ADP-ribosylation factor (Arf) GTPases involved in membrane trafficking, cytoskeletal remodeling, and cellular signaling. CENTG1/AGAP1 contains distinct functional domains: a GTPase-like domain, ankyrin repeats, and a pleckstrin homology (PH) domain, enabling interactions with membranes, lipids, and other signaling molecules. It plays a role in endocytic trafficking, receptor sorting, and neuronal development, with implications in cancer, neurological disorders, and immune regulation.
CENTG1 antibodies are essential tools for studying the protein's expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CENTG1's role in cellular processes or disease contexts. For example, elevated CENTG1 expression has been linked to tumor progression in certain cancers, while dysregulation is associated with neurodevelopmental conditions. Researchers also utilize these antibodies to explore CENTG1's interaction with molecular partners, such as the adaptor protein AP-3. or its modulation by post-translational modifications. Commercial CENTG1 antibodies are typically validated for specificity across human, mouse, and rat samples, supporting cross-species translational research.
×
