| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Low-density lipoprotein receptor-related protein 1B, LRP-1B, Low-density lipoprotein receptor-related protein-deleted in tumor, LRP-DIT, LRP1B, LRPDIT |
| Entrez GeneID | 53353 |
| WB Predicted band size | 515.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LRP1B antibody is generated from a mouse immunized with a recombinant protein human LRP1B. |
+ +
以下是关于LRP1B抗体的3篇参考文献，涵盖其功能研究与临床应用方向：
1. **标题**：*LRP1B: A Giant Lost in Cancer*
**作者**：Marsico, G., et al.
**摘要**：该综述总结了LRP1B基因在多种癌症中的高频缺失突变特征，强调其作为肿瘤抑制因子的潜在作用。文献提到利用特异性抗体检测LRP1B蛋白表达缺失与肿瘤进展的相关性，提示其在癌症诊断中的生物标志物价值。
2. **标题**：*LRP1B suppresses EMT and invasion of metastatic gastric cancer by negatively regulating the TGF-β/Smad4 pathway*
**作者**：Wang, Z., et al.
**摘要**：研究通过免疫共沉淀(使用LRP1B抗体)和Western blot技术，揭示LRP1B通过抑制TGF-β/Smad4信号通路阻碍胃癌细胞上皮-间质转化(EMT)，从而抑制转移。实验证明LRP1B低表达与患者不良预后相关。
3. **标题**：*The role of LRP1B in modulating cholesterol uptake and breast cancer progression*
**作者**：Liu, Y., et al.
**摘要**：该研究利用LRP1B抗体进行细胞定位和功能分析，发现LRP1B通过调控低密度脂蛋白受体通路影响乳腺癌细胞的胆固醇代谢，其表达缺失导致癌细胞增殖和侵袭能力增强，为靶向代谢通路治疗提供依据。
(注：以上文献信息为模拟示例，实际引用时需核对原文准确性。)
LRP1B (Low-Density Lipoprotein Receptor-Related Protein 1B) is a member of the LDL receptor family, primarily known for its role in cellular signaling, lipid metabolism, and endocytosis. The LRP1B gene, located on chromosome 2q21.2. is frequently associated with tumor suppression due to its frequent deletion or epigenetic silencing in various cancers, including lung, breast, and gastric cancers. It shares structural homology with LRP1. featuring ligand-binding domains, epidermal growth factor (EGF) repeats, and a cytoplasmic tail involved in protein-protein interactions. However, LRP1B exhibits distinct functional properties, such as attenuated endocytic activity, potentially influencing pathways like Wnt/β-catenin and TGF-β signaling.
Antibodies targeting LRP1B are critical tools for studying its expression, localization, and mechanistic roles in both normal physiology and disease. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to assess LRP1B protein levels in tissues or cell lines, particularly in cancer research. Reduced LRP1B expression, often linked to promoter hypermethylation or genomic deletions, correlates with poor prognosis in malignancies, making these antibodies valuable for biomarker studies. Additionally, LRP1B antibodies aid in exploring its interactions with extracellular ligands (e.g., fibronectin) or intracellular adaptors, shedding light on its tumor-suppressive functions. Despite challenges in specificity due to homology with LRP1. advanced validation methods ensure reliable detection, supporting ongoing research into LRP1B’s therapeutic potential in oncology.
×
