| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C-Jun-amino-terminal kinase-interacting protein 1, JIP-1, JNK-interacting protein 1, Islet-brain 1, IB-1, JNK MAP kinase scaffold protein 1, Mitogen-activated protein kinase 8-interacting protein 1, MAPK8IP1, IB1, JIP1, PRKM8IP |
| Entrez GeneID | 9479 |
| WB Predicted band size | 77.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This JIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-498 amino acids from the C-terminal region of human JIP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于JIP1抗体的3篇文献示例(注：文献信息为模拟概括，实际引用需核实)：
---
1. **文献名称**：*The JNK signal transduction pathway*
**作者**：Whitmarsh AJ, Davis RJ
**摘要**：该综述总结了JNK信号通路的调控机制，重点提及JIP1(JNK-interacting protein 1)作为支架蛋白的功能，并描述了其抗体的应用(如免疫沉淀和定位研究)，以阐明JIP1在细胞应激反应中的作用。
2. **文献名称**：*JIP1 mediates anterograde transport of TrkA receptors in neurons*
**作者**：Verhey KJ, Meyer AE, Dickinson DJ
**摘要**：研究利用JIP1特异性抗体(Western blot和免疫荧光)证明JIP1通过协调动力蛋白复合体，调控神经细胞中TrkA受体的轴突运输，为神经发育和退行性疾病提供机制见解。
3. **文献名称**：*Altered expression of JIP1 in Alzheimer's disease models*
**作者**：Yoon SY, Park JS, Kim JH
**摘要**：通过JIP1抗体检测阿尔茨海默病小鼠脑组织，发现JIP1与淀粉样前体蛋白(APP)的共定位增强，提示JIP1可能参与疾病相关的异常蛋白运输过程。
---
**注意**：以上文献信息为示例性质，实际文献需通过PubMed或学术数据库检索确认。建议使用关键词“JIP1 antibody”、“JNK-interacting protein 1”或“MAPK8IP1”结合具体研究领域进一步筛选。
The JIP1 antibody targets the c-Jun N-terminal kinase (JNK)-interacting protein 1 (JIP1), a scaffold protein critical for regulating the JNK signaling pathway. JIP1. encoded by the *MAPK8IP1* gene, organizes JNK cascade components (e.g., MAPK kinases) to facilitate specific signaling responses. Primarily expressed in neurons, JIP1 modulates stress-induced JNK activation, influencing processes like apoptosis, inflammation, and neuronal development. Dysregulation of JIP1 is linked to neurodegenerative diseases, including Alzheimer's, where aberrant JNK signaling contributes to tau pathology and neuronal death.
JIP1 also plays roles beyond the brain, such as regulating insulin secretion in pancreatic β-cells and glucose metabolism. Its isoforms (JIP1a, JIP1b) exhibit tissue-specific expression, expanding its functional diversity. Researchers use JIP1 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization, and interactions in disease models or cellular contexts. These studies aim to clarify JIP1’s mechanistic contributions to pathophysiology and explore therapeutic strategies targeting JNK pathways. Commercial JIP1 antibodies are typically validated for specificity against conserved domains or isoform-unique regions.
×
