Rabbit Polyclonal NT5C3 Antibody

The NT5C3 antibody targets the NT5C3 protein, also known as cytosolic 5'-nucleotidase III (cN-III) or cN-IIIB, which belongs to the 5'-nucleotidase family. This enzyme catalyzes the dephosphorylation of nucleoside monophosphates, such as inosine monophosphate (IMP) and guanosine monophosphate (GMP), to their corresponding nucleosides (e.g., inosine, guanosine). NT5C3 plays a critical role in purine metabolism, nucleotide recycling, and maintaining intracellular nucleotide balance, which is essential for DNA/RNA synthesis, energy transfer, and cellular signaling. Dysregulation of NT5C3 activity has been linked to metabolic disorders, cancer progression, and drug resistance, particularly in hematologic malignancies where mutations in NT5C3 are associated with relapse in acute lymphoblastic leukemia (ALL). The NT5C3 antibody is widely used in research to study the protein's expression, localization, and function in normal and pathological conditions. It enables detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into its role in nucleotide homeostasis, cellular proliferation, and disease mechanisms. Research utilizing this antibody contributes to understanding NT5C3's potential as a therapeutic target or biomarker in cancers and metabolic syndromes.