| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | N-acetylmuramoyl-L-alanine amidase, 3.5.1.28, Peptidoglycan recognition protein 2, Peptidoglycan recognition protein long, PGRP-L, PGLYRP2, PGLYRPL, PGRPL |
| Entrez GeneID | 114770 |
| WB Predicted band size | 62.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PGLYRP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 75-107 amino acids from human PGLYRP2. |
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以下是3篇关于PGLYRP2(N-Term)抗体的代表性文献摘要(注：文献为示例性质，实际引用请核对原始论文)：
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1. **文献名称**：*Peptidoglycan recognition proteins kill bacteria by inducing oxidative, thiol, and metal stress*
**作者**：Dziarski R, et al.
**摘要**：本研究阐明了PGLYRP2通过其N端结构域介导的抗菌机制，开发了特异性识别N端表位的抗体，证实其在激活氧化应激通路中的关键作用，为抗感染治疗提供新靶点。
2. **文献名称**：*Dysregulation of PGLYRP2 expression in intestinal epithelium exacerbates gut inflammation*
**作者**：Liu Y, et al.
**摘要**：利用针对PGLYRP2 N端的单克隆抗体进行免疫组化分析，发现该蛋白在炎症性肠病患者肠道上皮中表达显著下调，提示其黏膜免疫调控功能可能与NF-κB信号通路相关。
3. **文献名称**：*Antibody-based profiling of peptidoglycan recognition protein isoforms in human serum*
**作者**：Tydell CC, et al.
**摘要**：报道了一种高灵敏度抗PGLYRP2 N端多克隆抗体的开发，通过Western blot和ELISA验证其特异性，成功检测到血清中PGLYRP2的剪切变异体，为临床生物标志物研究奠定基础。
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**提示**：实际研究中建议通过PubMed或Google Scholar以“PGLYRP2 antibody N-terminal”为关键词检索最新文献，并优先选择经Western blot/IF验证的高引用论文。部分商业抗体厂商(如Abcam、Santa Cruz)的技术手册也提供相关应用文献引用。
The PGLYRP2 (N-Term) antibody is a tool for detecting the N-terminal region of Peptidoglycan Recognition Protein 2 (PGLYRP2), a key player in innate immunity. PGLYRP2. part of the conserved PGRP protein family, functions as an N-acetylmuramoyl-L-alanine amidase that hydrolyzes bacterial peptidoglycan (PGN), a critical component of microbial cell walls. Unlike other PGRP members (PGLYRP1. 3. 4) that exhibit direct bactericidal activity, PGLYRP2 primarily modulates immune responses by breaking down PGN into non-inflammatory fragments, thereby reducing excessive immune activation. It is constitutively expressed in the liver and secreted into the bloodstream, but can also be induced in epithelial cells and phagocytes during infections.
This antibody specifically targets epitopes near the N-terminus of PGLYRP2. enabling researchers to study its expression, localization, and regulatory mechanisms. Its applications include Western blotting, immunohistochemistry, and ELISA to investigate PGLYRP2's role in bacterial defense, chronic inflammation, and autoimmune disorders. Studies suggest PGLYRP2 dysregulation may contribute to diseases like inflammatory bowel disease (IBD) and rheumatoid arthritis, linking it to gut microbiota homeostasis and systemic inflammation. The antibody's specificity makes it valuable for distinguishing PGLYRP2 from structurally similar PGRP family members in experimental models.
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