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Rabbit Polyclonal MGAT4B(N-Term) Antibody

  • 中文名： MGAT4B (N-Term)抗体
  • 别    名： Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B, 2.4.1.145, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb, GlcNAc-T IVb, GnT-IVb, N-acetylglucosaminyltransferase IVb, UDP-N-acetylglucosamine: alpha-1,
货号: IPDX33815
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAlpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B, 2.4.1.145, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb, GlcNAc-T IVb, GnT-IVb, N-acetylglucosaminyltransferase IVb, UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb, MGAT4B
Entrez GeneID11282
WB Predicted band size63.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis MGAT4B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-62 amino acids from human MGAT4B.

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参考文献

以下是关于MGAT4B (N-Term)抗体的3篇示例参考文献(注：文献为示例，非真实存在)：

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1. **"MGAT4B regulates hepatocellular carcinoma progression via STAT3 signaling"**

*Zhang Y, et al. (2020)*

摘要：研究通过Western blot和免疫组化(使用MGAT4B N-Term抗体)发现MGAT4B在肝癌组织中高表达，并通过STAT3通路促进肿瘤侵袭，提示其作为潜在治疗靶点。

2. **"Characterization of a polyclonal antibody targeting the N-terminal domain of MGAT4B"**

*Wang L, et al. (2018)*

摘要：报道了一种针对MGAT4B N端结构域的抗体制备与验证，该抗体成功用于免疫沉淀和免疫荧光，证实其特异性及在糖基化酶功能研究中的应用。

3. **"MGAT4B-mediated glycosylation promotes breast cancer metastasis"**

*Liu X, et al. (2019)*

摘要：利用MGAT4B N-Term抗体敲低蛋白表达，发现MGAT4B通过调控β1-整合素糖基化增强乳腺癌细胞迁移，为靶向糖基化治疗提供依据。

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如需真实文献，建议通过PubMed或Google Scholar以关键词“MGAT4B antibody N-terminal”检索，并筛选涉及抗体应用的实验研究。

背景信息

The MGAT4B (N-Term) antibody is designed to target the N-terminal region of the MGAT4B protein, a key enzyme in N-glycan biosynthesis. MGAT4B (Mannosyl (Alpha-1.3-)-Glycoprotein Beta-1.4-N-Acetylglucosaminyltransferase, Isozyme B) catalyzes the formation of β1.4-branched N-linked oligosaccharides, influencing glycoprotein structure and function. This enzyme is critical in regulating cell adhesion, immune response, and protein stability, with dysregulation linked to cancer metastasis, autoimmune diseases, and metabolic disorders. The N-terminal domain, where the antibody binds, is involved in substrate recognition and enzymatic activity. Researchers use this antibody in applications like Western blotting, immunohistochemistry, and flow cytometry to study MGAT4B expression patterns, localization, and its role in disease mechanisms. Its specificity for the N-terminal region helps distinguish MGAT4B from homologous family members (e.g., MGAT4A) and detect potential post-translational modifications. Studies have highlighted elevated MGAT4B levels in certain cancers, suggesting its utility as a biomarker or therapeutic target. The antibody's validation in multiple experimental models underscores its importance in glycobiology and translational research.

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