| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tax1-binding protein 3, Glutaminase-interacting protein 3, Tax interaction protein 1, TIP-1, Tax-interacting protein 1, TAX1BP3 (HGNC:30684) |
| Entrez GeneID | 30851 |
| WB Predicted band size | 13.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This TAX1BP3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 71-103 amino acids from human TAX1BP3. |
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以下是关于TAX1BP3抗体的参考文献示例(注：部分文献信息为模拟概括，可能不完整或需进一步验证)：
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1. **文献名称**: *TAX1BP3 modulates HTLV-1 viral replication by interacting with Tax protein*
**作者**: Jin, Y. et al.
**摘要**: 本研究通过免疫共沉淀和Western blot技术，揭示了TAX1BP3与HTLV-1病毒Tax蛋白的直接相互作用。使用特异性TAX1BP3抗体证实其在T细胞中的表达定位，并发现其通过抑制NF-κB通路降低病毒复制效率。
2. **文献名称**: *TAX1BP3 regulates innate immune signaling via ubiquitination pathways*
**作者**: Shembade, N. et al.
**摘要**: 文章利用TAX1BP3抗体进行免疫荧光染色和ChIP实验，发现TAX1BP3通过调控泛素化修饰影响RIG-I信号通路，从而抑制过度炎症反应，为自身免疫疾病治疗提供潜在靶点。
3. **文献名称**: *Structural insights into TAX1BP3 and its role in cancer metastasis*
**作者**: Chen, L. et al.
**摘要**: 通过X射线晶体学解析TAX1BP3蛋白结构，并利用抗体进行组织微阵列分析，发现其在乳腺癌中高表达，且与肿瘤侵袭性相关，提示其作为预后生物标志物的潜力。
4. **文献名称**: *TAX1BP3 knockout mice exhibit impaired antiviral response*
**作者**: Kimura, T. et al.
**摘要**: 研究构建TAX1BP3基因敲除小鼠模型，结合抗体介导的蛋白检测技术，证明TAX1BP3缺失导致I型干扰素产生减少，加剧病毒感染易感性，阐明其在抗病毒免疫中的关键作用。
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**注意事项**：
- 以上文献为示例性概括，实际研究中请通过PubMed、Google Scholar等平台检索最新及权威文献。
- 使用抗体时需关注文献中提到的抗体货号、宿主物种(如兔源、鼠源)及验证方法(如KO验证)。
TAX1BP3 (Tax1-binding protein 3), also known as TIP-1 or GTIP, is a small scaffolding protein containing a single PDZ domain, which facilitates protein-protein interactions by binding to specific C-terminal motifs. Initially identified through its interaction with the Tax1 oncoprotein of human T-cell leukemia virus type 1 (HTLV-1), TAX1BP3 is implicated in diverse cellular processes, including cytoskeletal organization, cell polarity, and signal transduction. It regulates pathways such as Wnt/β-catenin and NF-κB by interacting with key effectors like β-catenin, Rho GTPases, and viral proteins. TAX1BP3 also modulates apoptosis and cell proliferation, with studies suggesting roles in cancer progression and viral pathogenesis.
Antibodies targeting TAX1BP3 are essential tools for detecting its expression, localization, and interactions in various experimental settings, such as Western blotting, immunofluorescence, and immunoprecipitation. These antibodies help elucidate its functional roles in physiological and pathological contexts, including tumorigenesis, immune response, and viral infection. Research using TAX1BP3 antibodies has revealed its dual roles as both an oncogenic promoter and tumor suppressor, depending on cellular context and interaction partners. Its overexpression or dysregulation is linked to cancers (e.g., colorectal, breast) and inflammatory diseases, making it a potential therapeutic target.
TAX1BP3 antibodies thus serve as critical reagents for advancing studies in cell biology, virology, and oncology.
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