Rabbit Polyclonal NRIP2 Antibody

The NRIP2 (Nuclear Receptor Interacting Protein 2) antibody is a research tool designed to detect and study the NRIP2 protein, also known as RIP140 (Receptor-Interacting Protein 140). NRIP2 is a transcriptional coregulator that interacts with nuclear receptors, such as estrogen and thyroid hormone receptors, modulating their transcriptional activity. It plays a role in diverse biological processes, including metabolism, reproduction, and cellular differentiation, by recruiting chromatin-modifying enzymes to target gene promoters or enhancers. Dysregulation of NRIP2 has been linked to metabolic disorders, cancer progression, and reproductive dysfunction. Antibodies targeting NRIP2 are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, subcellular localization, and interactions in various tissues or disease models. These antibodies are critical for elucidating NRIP2's role in gene regulation and its potential as a therapeutic target. Validation of NRIP2 antibodies typically includes testing for specificity (e.g., knockdown/knockout controls) and cross-reactivity assessments to ensure accurate detection across species (e.g., human, mouse, rat). Their applications span basic research in molecular biology, oncology, and endocrinology.