Rabbit Polyclonal TP53RK Antibody

The TP53RK (TP53-regulating kinase) antibody is a crucial tool in studying the functional role of the TP53RK protein, a serine/threonine kinase encoded by the TP53RK gene. This kinase is part of the evolutionarily conserved FAM82 family and plays a regulatory role in the p53 signaling pathway, which is central to tumor suppression, DNA repair, and apoptosis. TP53RK phosphorylates p53 at specific residues, enhancing its stability and transcriptional activity under stress conditions, thereby promoting cell cycle arrest or programmed cell death in response to DNA damage. Dysregulation of TP53RK has been implicated in various cancers, with studies suggesting its dual role as a tumor suppressor or oncogene depending on cellular context. The TP53RK antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression levels, localization, and post-translational modifications in both normal and diseased tissues. Its application extends to exploring TP53RK's interaction with other proteins in stress-response pathways, as well as evaluating its potential as a biomarker for cancer prognosis or therapeutic targeting. Researchers also utilize this antibody to investigate TP53RK's involvement in non-cancer pathologies, such as neurodegenerative disorders, where p53 signaling may contribute to disease progression.