Rabbit Polyclonal RPH3AL Antibody

The RPH3AL antibody targets the RPH3AL protein, also known as Rabphilin-3A-like, a member of the Rab effector family involved in intracellular vesicle trafficking and neurotransmitter release. RPH3AL shares structural homology with Rabphilin-3A, including N-terminal zinc-finger domains that bind Rab3A/Rab27 GTPases and C-terminal C2 domains implicated in calcium-dependent membrane interactions. It is predominantly expressed in the brain, particularly in synaptic regions, where it regulates synaptic vesicle docking, fusion, and exocytosis by interacting with Rab3A and components of the SNARE complex. Dysregulation of RPH3AL has been linked to neurological disorders, including autism spectrum disorders and schizophrenia, due to its role in synaptic plasticity. RPH3AL antibodies are widely used in neuroscience research to study synaptic function, protein localization, and molecular mechanisms underlying vesicle trafficking. They are employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize RPH3AL expression patterns in neural tissues or cultured cells. Commercial RPH3AL antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown. Recent studies also explore its potential involvement in neurodegenerative diseases, making it a biomarker of interest for understanding synaptic pathology.